摘要
目的 探讨胰腺癌组织中骨形成蛋白和激活素的跨膜抑制剂（BAMBI）的表达及其临床意义.方法 应用免疫组化方法检测69例胰腺癌组织和36例癌旁正常胰腺组织中BAMBI的表达,分析其与胰腺癌临床病理参数和患者生存率的关系.结果 胰腺癌组织中BAMBI的阳性表达率明显高于正常胰腺组织（56.5％比16.7％,P＜0.01）.胰腺癌组织BAMBI的表达与患者年龄、性别及肿瘤大小、分化程度无相关性,但淋巴结转移组BAMBI阳性表达率高于无淋巴结转移组（67.4％比38.5,P=0.019）,TNM分期Ⅲ期组BAMBI阳性表达率高于Ⅰ＋Ⅱ期组（75.0比31.0％,P=0.001）.胰腺癌组织BAMBI阳性患者的中位生存时间为6个月,显著低于BAMBI阴性组的10个月（P=0.035）.结论 胰腺癌组织高表达BAMBI,BAMBI的高表达与肿瘤淋巴结转移、TNM分期、分化程度及患者预后有关.
Objective To investigate the expression of BAMBI in pancreatic carcinoma tissue and its clinical value.Methods Expression of BAMBI was detected by immunohistochemistry in 69 cases of pancreatic cancer and 15 normal pancreatic samples.The survival and its association with clinicopathologic parameters were analyzed.Results The expression of BAMBI in the cancer tissue was much higher than that in the normal tissues （56.5% vs 16.7%,P 〈0.01）.The expression of BAMBI was not associated with age,sex and tumor size,differentiation,but expression of BAMBI in patient with lymph node metastasis was higher than that in patient without lymph node metastasis （67.4% vs 38.5%,P =0.019）,the expression of BAMBI in TNM stage Ⅲ was higher than that in stage Ⅰ ＋ Ⅱ （75.0% vs 31.0%,P =0.001）.The median survival of BAMBI-positive group （6 months） was lower than that of BAMBI-negative group （10 months）.Conclusions BAMBI is over-expressed in pancreatic carcinoma,and its expression is associated with lymph node metastasis,TNM staging,differentiation and prognosis.
出处
《中华胰腺病杂志》
CAS
2015年第2期78-80,共3页
Chinese Journal of Pancreatology
基金
国家自然科学基金（81470889）
