摘要
目的 观察血糖和血脂水平变化以及糖尿病对肝硬化患者疾病恶化的影响.方法 对2010-2014年,宁波慈溪市人民医院收治268例肝硬化患者,根据Child-Pugh评分标准分为三组,比较三组患者血糖、血脂水平以及糖尿病的发生率,并进一步观察糖尿病对肝硬化患者肝肾功能以及并发症的影响.结果 Child B级和C级肝硬化患者糖尿病的发生率明显高于Child A级,P=0.004,而三组空腹血糖受损（IFG）的发生率无统计学差异,P=0.819;Child B级和C级肝硬化患者总胆固醇（TC）水平明显要低于Child A级,P＜0.01;而三组空腹血糖、甘油三脂（TG）水平差异无统计学意义,P =0.558,0.169.合并糖尿病的肝硬化患者血清白蛋白（ALB）水平明显低于无糖尿病的患者,P=0.009;合并糖尿病的肝硬化患者腹水、消化道出血、肝性脑病并发症发生率均明显高于无糖尿病的患者,P ＜0.01.结论 肝硬化患者糖代谢异常发生率更高,且合并的糖尿病会促进肝硬化的恶化.
Objective To explore the impact of glucose and lipid metabolism and diabetes on the progression of disease in patients with cirrhosis.Methods A total of 268 cases of patients with cirrhosis,treated at our hospital from 2010 to 2014,were divided into three groups according to standard of Child-Pugh grading score.The blood glucose,blood lipid leveland the incidence of diabetes mellitus （DM） were observed and compared respectively.The impact of diabetes on liver and renal function and complication in patients with cirrhosis was further observed.Results The incidence of DM in patients with cirrhosis of Child-Pugh B and C was singnifcantly higher than that of Child-Pugh A,P =0.004,while there was no significant difference in impaired fasting blood glucose（IFG）,P =0.819.The level of total cholesterol （TC） in patients with cirrhosis of Child-Pugh B and C was obviously lower than that of Child-Pugh A,P =0.000,while the levels of fasting blood glucose,triglycerides （TG） in patients with different Child-Pugh score had no statistically significant difference,P =0.558,0.169.The level of serum albumin （ALB） of patients with DM in cirrhosis was significantly lower than those without DM,P =0.009.The patients with DM in liver cirrhosis had higher incidence of complications such as ascites,gastro esophageal variceal bleeding（GEVB） or hepatic encephalopathy than those without DM,P =0.000.Conclusion The patients with cirrhosis had higher incidence of abnormal glucose metabolism,and DM lead to progression of liver disease in turn.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2015年第2期142-144,共3页
Chinese Journal of Experimental and Clinical Virology
关键词
肝硬化
血糖
高脂血症
糖尿病
肝硬化/并发症
Liver cirrhosis
Blood glucose
Hyperlipidemia
Diabetes mellitus
Live cirhosis/complications
