摘要
目的 探讨银屑病发病危险因素及季节变化对银屑病病情的影响.方法 将寻常性银屑病患者根据就诊时间分为夏秋组和冬春组,通过调查表了解其工作环境（户外、室内）、遗传、性别、年龄、精神、吸烟、饮酒、感染等因素,通过银屑病面积和严重程度指数（PASI）评分判定患者病情情况.结果 不同季节就诊患者人次无明显区别,但冬春组患者病情（PASI评分15.6±6.2）明显重于夏秋组（PASI评分10.3±5.7）（P ＜0.01）.夏秋组患者户外工作比例（31.5％）明显高于冬春组（22.0％）（P＜0.05）,而冬春组患者发病前精神诱因发生率（26.3％）及发病前2周感染诱因发生率（23.6％）明显高于夏秋组（12.5％、13.7％）（均P＜ 0.01）.结论 不同季节就诊患者职业环境及发病诱因有明显区别,说明季节和环境因素在寻常性银屑病发病过程中起重要作用.
Objective To investigate risk factors for the occurrence of psoriasis,and to estimate the influence of seasonal variation on the severity of psoriasis.Methods Totally,507 patients with psoriasis vulgaris were divided into two groups according to the time of clinic visits：summer-fall group （n =248） and winter-spring group （n =259）.Questionnaires were used to investigate possible risk factors for psoriasis,including work environment （outdoor or indoor）,heredity,gender,age,spiritual factors,smoking,drinking,infections,etc.The severity of disease was evaluated according to psoriasis area and severity index （PASI）.Results There was no significant difference in the number of clinical visits made by patients with psoriasis vulgaris between different seasons,but the PASI score was significantly higher in the winter-spring group than in the summer-fall group （15.6 ± 6.2 vs.10.3 ± 5.7,P 〈 0.01）.The summer-fall group showed increased proportion of patients working outdoors （31.5% vs.22.0%,P 〈 0.05）,but decreased incidence rates of predisposing spiritual events （26.3% vs.12.5%,P 〈 0.01） and infections 2 weeks before the occurrence of psoriasis （23.6% vs.13.7%,P 〈 0.01）.Conclusions Occupational environment and predisposing factors markedly differ among psoriatic patients visiting to physicians in different seasons,hinting that seasonal and environmental factors play an important role in the pathogenesis of psoriasis vulgaris.
出处
《国际皮肤性病学杂志》
2015年第3期147-148,共2页
International Journal of Dermatology and Venereology
基金
山东省烟台市科技发展计划项目（2013YD002）
关键词
银屑病
季节
环境
危险因素
问卷调查
Psoriasis
Seasons
Environment
Risk factors
Questionnaires
