摘要
HBV感染过程受多种因素的综合调控。白细胞介素(IL)10是免疫调节的必需因子,IL-10基因启动子多态性影响IL-10 mRNA的转录,从而影响血清IL-10水平。IL-10与HBV感染转归、预后有关联。简述了IL-10基因多态性与血清IL-10的关系和IL-10基因多态性与HBV感染转归的联系,对IL-10作为炎症反应抑制因子,在机体免疫功能、HBV感染转归、HBV发展及其相关并发症的发生发展方面的作用进行了综述。认为IL-10基因多态性及血清IL-10与HBV感染后炎症反应关系密切,影响机体清除HBV,并与HBV感染肝损害程度、HBV感染肝硬化、HBV相关肝细胞癌有关。检测IL-10基因及血清水平对预测HBV感染转归有一定的指导意义。
Multiple etiological factors are integrally involved in the development of hepatitis B virus （HBV）infection.Interleukin-10 （IL-10）is an essential cytokine of immune regulation,and IL-10 gene promoter polymorphism affects its mRNA transcription and serum level. IL-10 is related to the prognosis of HBV infection.This review briefly discusses the association of IL-10 gene polymorphism and its serum level with the prognosis of HBV infection,and summarizes the role of IL-10,as an anti-inflammatory cytokine,in host immune function, the prognosis and progression of HBV infection,and HBV-related complications.IL-10 gene polymorphism and its serum level are closely associated with inflammatory response after HBV infection,influence HBV clearance,and are related to the severity of HBV-related liver injury,liver cirrhosis,and hepatocellular carcinoma.The determination of IL-10 gene and serum levels may provide a predictive marker for the prognosis of HBV infection.
出处
《临床肝胆病杂志》
CAS
2015年第4期618-621,共4页
Journal of Clinical Hepatology
