摘要
甲状腺功能减退症（甲减）是常见的内分泌系统疾病之一，其治疗措施依赖甲状腺激素的终身替代，而常规使用左旋甲状腺素（L-T4）治疗是目前各大权威指南推荐的主要方案。但一部分接受L-T4治疗的患者，尽管促甲状腺激素水平正常，仍然持续存在一些非特异性的不适症状，对L-T4治疗产生不满的情绪。近年关于L-T4和三碘甲状腺氨酸（L-T3）联合治疗的研究引起了对于目前甲减治疗方案的反思和讨论。将来需要设计前瞻性研究为L-T4和L-T3联合治疗提供更多的循证医学证据。
Hypothyroidism is a common endocrine disease. Its treatment depends on thyroid hormone replacement therapy. Currently, levothyroxine （L-T4） is the preparation recommended by many guidelines. However, there are some L-T4-treated patients with normal TSH levels and persistent non-specific symptoms and discomforts. Therefore, combination therapy with L-T4 and liothyronine （L-T3） has been considered as an alternative option for hypothyroidism. However, more prospective studies are needed to provide evidence-based effects for this kind of regimen.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2015年第4期296-299,共4页
Chinese Journal of Endocrinology and Metabolism
