摘要
目的探讨2型糖尿病（T2DM）患者骨密度（BMD）情况及其合并骨质疏松症（OP）的相关影响因素。方法采用双能X线骨密度仪（DEXA）测定220例T2DM患者股骨颈（N）及腰椎1-4（L1-4）的BMD,按BMD分为骨含量正常、骨含量减少及OP组,比较各组临床、生化指标,分析T2DM合并OP的影响因素。结果 OP组女性比例、年龄、T2DM病程、糖化血红蛋白（Hb A1c）高于骨含量正常组和骨含量减少组,体质指数（BMI）低于骨含量正常组和骨含量减少组、高密度脂蛋白胆固醇（HDL-C）低于骨含量正常组而高于骨含量减少组;骨含量减少组年龄、T2DM病程、Hb A1c高于骨含量正常组,BMI、HDL-C低于骨含量正常组（均P〈0.05）;3组腰臀比、收缩压（SBP）、舒张压（DBP）、绝经后女性（PMW）比例、空腹血糖（FPG）、餐后2 h血糖（2 h PG）、血磷、血钙、总胆固醇（TC）、三酰甘油（TG）和低密度脂蛋白胆固醇（LDL-C）差异无统计学意义。高龄、女性、T2DM病程长、高FPG、高2 h PG,高Hb A1c为T2DM患者合并OP的危险因素。结论高龄、女性T2DM患者为发生OP的高危人群,应定期监测其血糖及Hb A1c等指标,及时调整治疗方案。
Objective To explore related factors affecting bone mineral density （BMD） and osteoporosis （OP） in patients with type 2 diabetes mellitus （T2DM）. Methods Dual-energy X-ray absorptiometry was used to measure BMD of the femoral neck and the lumbar vertebrae in 220 patients with T2DM. All the patients were divided into three groups： normal bone mass group, decreased bone mass group and OP group according to the value of BMD. The clinical data and biochemical indicators were compared and analyzed between these groups, and the influencing factors of T2DM and OP were explored. Results Compared with normal bone mass group and decreased bone mass group, there were more older patients, longer course of T2DM, lower BMI and high density lipoprotein cholesterol （HDL-C）, and higher glycated hemoglobin （HbAle） level in OP group. There were significantly higher age, longer course of T2DM, higher level of HbAlc, and lower levels of BMI, HDL-C in decreased bone mass group than those of normal bone mass group （P〈0.05）. There were no significant differences in waist-to-hip ratio, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, postmenopausal women （PMW） ratio, fasting plasma glucose （FPG）, 2-h postprandial blood glucose （2hPG）, blood phosphorus, calcium, total choles- terol （TC）, three acyl glycerin （TG） and low-density lipoprotein cholesterol （LDL-C） between three groups. The risk factors for T2DM combined with OP were older, female, long duration of T2DM, higher levels of FPG, 2hPG and HbAle. Conclusion Older and female T2DM patients were high-risk group of OP. The treatment plan should be timely adjusted by regularly monitoring indexes of blood glucose and HbA lc.
出处
《天津医药》
CAS
2015年第5期505-507,共3页
Tianjin Medical Journal
基金
兵团科技支疆项目(2014AB049)
