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质粒介导的耐药基因水平传播研究进展 被引量:10

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摘要 质粒是细菌染色体外能够自我复制的DNA分子,携带耐药基因的质粒能对包括β-内酰胺类、大环内酯类、氨基糖苷类、喹诺酮类、磺胺类、四环素类、氯霉素类等抗生素产生耐药性([1])。其介导的耐药基因可随移动遗传元件(插入序列、转座子)在细菌间发生水平传播([2]),是社区和住院病人获得性感染的主要致病机制。目前,从临床菌株分离的质粒大部分来自埃希菌属、沙门菌属和肺炎克雷伯菌属等肠杆菌科细菌。而不动杆菌属分离的质粒大部分来自鲍曼不动杆菌(http://www.ncbi.nlm.nih.gov/nuccore/,Oct 2014)。本文将对革兰阴性杆菌中的碳青霉烯酶、CTX-M型超广谱β-内酰氨酶(ESBL)和质粒介导的喹喏酮类耐药(PMQR)基因进行综述。
机构地区 丽水市人民医院
出处 《中国卫生检验杂志》 CAS 2015年第8期1288-1292,1296,共6页 Chinese Journal of Health Laboratory Technology
基金 浙江省自然科学基金(LY12H19003)
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