摘要
聚羟基乙酸(PGA)和聚乳酸(PLA)是两种生物相容性良好且可在体内降解的材料.采用PGA/PLA编织线经手工编织的方法制备成周向6个方格、直径为11mm的圆筒形网套,作为方格网状结构肌腱支架增强体,测试其初始几何性能及拉伸性能,将编织所得的方格网状肌腱支架增强体放入温度为37℃、pH值为7.4的磷酸盐缓冲液(PBS)中进行为期8星期的体外降解实验,观察支架增强体在体外降解过程中的外观、孔隙率、厚度、口径以及断裂强力和质量损失的变化规律.研究发现,手工编织方格网状结构肌腱支架增强体具有纵向拉伸断裂强力较大、纵向延伸性小和孔隙率大、不易脱散等特性.
Both polyglycolic acid（PGA） and polylactic acid（PLA） filaments have the biocompatible and degradable properties. The specific proportion of PGA/PLA braided yarn was selected to form the square-mesh scaffold reinforcements for tendon by hand-knitting with the circumferential six squares and 11 mm diameter around. Their initial geometric properties and tensile properties were tested. The square- mesh scaffold reinforcements were put into phosphate buffered saline （PBS） with 37 ℃, pH value was 7.4 for a period of eight-week degradation in vitro. Each sample was investigated on its basic performance of surface morphology, porosity, thickness, caliber and tensile strength as well as the change of mass loss during the eight-week degradation periods. The experimental results showed that the square-mesh scaffold reinforcements have the properties of bigger longitudinal tensile strength, smaller longitudinal extension, larger porosity and it＇s difficult to decoherence.
出处
《东华大学学报（自然科学版）》
CAS
CSCD
北大核心
2015年第2期178-182,共5页
Journal of Donghua University(Natural Science)
基金
国家大学生创新性实验计划资助项目(201210255027)
