摘要
目的探讨比索洛尔治疗高血压慢性心力衰竭的临床疗效和安全性。方法选取2013年2月至2014年2月文登中心医院收治的慢性心力衰竭患者60例，按照随机数字表法分为观察组和对照组，每组30例。对照组给予常规抗心力衰竭治疗，观察组在对照组的基础上加用比索洛尔治疗，疗程均为4周。观察指标包括：治疗前后NYHA心功能分级、Lee心力衰竭积分、中医证候评分、生活质量评分、6min步行试验、超声心动图指标及血浆N-末端脑钠肽前体（NT-proBNP）、凋亡因子（Fas）、肿瘤坏死因子-α（TNF—α）、白细胞介素-6（IL-6）等细胞因子水平。结果治疗前各项观察指标比较差异未见统计学意义（P〉0．05）；两组治疗后心功能分级、Lee心力衰竭积分、生活质量评分、6min步行试验、超声心动图指标（E／A除外）及血浆NT—proBNP、Fas、TNF-α、IL-6等细胞因子水平均较治疗前明显改善，观察组改善情况明显优于对照组，差异有统计学意义（P〈0．05）。结论比索洛尔治疗高血压慢性心力衰竭临床疗效显著，值得临床推广应用。
Objective To study the clinical effect of Bisoprolol on chronic heart failure. Methods Sixty cases of hypertension chronic heart failure in Wendeng central hospital from February 2013 to February 2013 were divided into observation group and control group （30 cases in each group） ,according to random number table method. The control group was given conventional medicine treatment, the observation group was given the bisoprolol on the basis of the control group, a course of 4 weeks. Observation indexes including： NYHA cardiac function classification, Lee heart failure points, TCM syndrome score, quality of life score, 6 minutes walk test, echocardiographic indexes and plasma NT-proBNP, Fas, TNF- alpha, IL-6 levels before and after the treatment. Results Before the treatment, the observation indexes of the two group had no significant difference （ P 〉 0.05 ） ; The NYHA cardiac function classification, Lee heart failure points, TCM syndrome score, quality of life score, 6 minutes walk test, echocardiographic indexes and plasma NT-proBNP, Fas, TNF-alpha, IL-6 levels of the two groups after treatment was obviously improved than that of before treatment, the observation group was obviously superior to control group, the differences were significant （ P 〈 0.05 ）. Conclusions The clinical effect of bisoprolol on chronic heart failure is distinct, it is worthy of clinical application.
出处
《中国实用医刊》
2015年第11期4-6,共3页
Chinese Journal of Practical Medicine
关键词
慢性心力衰竭
心内科
比索洛尔
临床疗效
Chronic heart failure
Cardiology
Bisoprolol
Clinical curative effect
