摘要
目的分析唑来膦酸联合化疗在治疗肺癌骨转移中的效果。方法将修武县人民医院2010年1月至2013年12月收治的62例确诊为肺癌骨转移的患者作为观察对象，根据住院号随机分为观察组和对照组，每组31例。对照组采用诺维本联合顺铂治疗，观察组在此基础上联合唑来膦酸治疗。观察两组患者疼痛缓解情况、活动能力恢复情况、不良反应。结果观察组疼痛缓解总有效率为90．32％，对照组为61．29％，疼痛缓解情况优于对照组（P〈0．05）；观察组活动能力改善总有效率为83．87％，对照组总有效率为67．74％，活动能力改善情况优于对照组（P〈0．05）；两组患者不良反应发生率比较差异未见统计学意义（P〉0．05）。结论唑来膦酸联合化疗治疗肺癌骨转移可减轻疼痛，改善活动能力，值得借鉴。
Objective To analyze the effect of zoledronic acid in combination with chemotherapy on bone metastasis in lung cancer. Methods From January 2010 to December 2013, 62 patients diagnosed with lung eanoer bone metastasis in our hospital were chose as the observed objects, and were randomly divided into observation group and control group, with 31 cases in each group. Control group was given Naveibine plus cisplatin treatment, observation group was given zoledronic acid treatment in addition. The relief, the recovery of activity, adverse reactions were observed. Results The total efficiency of pain relief was 90. 32% in observation group, and 61.29% in the control group, there was significant difference between the two groups（ P 〈 0. 05 ） ; the overall efficiency of activity improvement was 83.87% in the observation group, and 67.74% in the control group, there was significant difference between the two groups （P 〈 0. 05 ） ; there was no significant difference in incidence of adverse reactions between the two groups （P 〉 0. 05 ）. Conclusions Zoledronic acid combined with chemotherapy for lung cancer bone metastasis can reduce pain, improve mobility, so it is worthy learning from.
出处
《中国实用医刊》
2015年第11期33-34,共2页
Chinese Journal of Practical Medicine
关键词
肺癌
骨转移
唑来膦酸
化疗
Lung cancer
Bone metastasis
Zoledronic acid
Chemotherapy
