摘要
目的制备盐酸多西环素(DXY)牙周用温度敏感型凝胶,并进行质量评价。方法采用冷法制备盐酸多西环素牙周用温敏凝胶,用倒置试管法测定胶凝温度和胶凝时间,流变仪测定流变学特征,透析袋法考察体外释放度。结果制得的盐酸多西环素牙周用温敏凝胶的胶凝温度为34℃,胶凝时间为(1.2±0.5)min,体外流动性好,37℃时黏度增大,缓释效果明显。结论盐酸多西环素牙周用温敏凝胶可满足牙周缓释用药和注射给药的要求。
Objective To prepare doxycycline hydrochloride thermosensitive gel for periodontal application and to evaluate its quality. Methods The cold method was adopted to prepare doxycycline hydrochloride thermosensitive gel for periodontal application. The gelling temperature and gelling time were determined by using the tube-invertion method,the rheological characteristics were investigated by the rheometer and the in vitro release was investigated by the dialysis bag method. Results The gelling temperature of the prepared doxycycline hydrochloride thermosensitive gel for periodontal application was 34 ℃ and its gelling time was（1. 2 ± 0. 5）min. The gel had good liquidity in intro,increased viscosity at 37 ℃ and good sustained release effect. Conclusion Doxycycline hydrochloride ther-mosensitive gel for periodontal application can meet the demands of periodontal sustained release medication and injection administration.
出处
《中国药业》
CAS
2015年第10期40-42,共3页
China Pharmaceuticals
关键词
牙周炎
盐酸多西环素
温敏凝胶
泊洛沙姆
periodontitis
doxycyline hydrochloride
thermosensitive gel
poloxamer
