摘要
目的：比较多西紫杉醇腹腔热灌注化疗与顺铂腹腔热灌注化疗治疗老年胃癌并恶性腹水的临床疗效。方法 KPS评分为50～70分的老年胃癌并恶性腹水患者80例随机分为观察组（多西紫杉醇腹腔热灌注化疗）40例和对照组（顺铂腹腔热灌注化疗）40例，观察2组近期疗效、生活质量（ KPS ）评分、肿瘤标记物（ CEA、CA125、CA199）及不良反应。结果观察组总有效率为70．0％（28／40），高于对照组47．5％（19／40）（χ2＝4．178， P ＜0．05）；疾病控制率为87．5％（35／40），高于对照组的67．5％（27／40）（χ2＝4．588， P ＜0．05）。治疗前KPS评分观察组、对照组分别为（56．50±5．80）分、（56．25±6．28）分，治疗后分别为（66．50±9．49）分、（68．25±8．44）分，2组均较其治疗前明显提高（ t ＝－6．817、－5．942， P ＜0．05）。2组治疗后较治疗前CEA、CA125、CA199水平明显降低（观察组t ＝6．593、2．189、1．606， P ＜0．05；对照组t ＝6．125、2．099、1．897， P ＜0．05），但治疗前、治疗后2组间均无明显差异（治疗前t ＝0．213、－0．973、0．103， P ＞0．05；治疗后t ＝－0．422、－0．945、0．872， P ＞0．05）。观察组胃肠道反应发生率为17．5％（7／40），较对照组的37．5％（15／40）。明显降低（χ2＝4．013， P ＜0．05）。结论多西紫杉醇腹腔热灌注化疗治疗老年胃癌并恶性腹水的疗效好，能提高患者生活质量，降低肿瘤标记物水平，不良反应轻。
Objective To compare the effect of docetaxel peritoneal perfusion and Cisplatin infusion chemotherapy in elderly with gastric cancer and malignant ascites.Methods Eighty cases of elderly patients with gastric cancer and malignant ascites with KPS score ranked from 50 to 70 points were randomly divided into research group （ docetaxel abdominal hot perfu-sion chemotherapy） with 40 cases and control group （ heat cisplatin intraperitoneal perfusion chemotherapy） with 40 cases, to observe the curative effect, KPS score, tumor markers and adverse reactions of the two groups of patients.Results The total effective rate of research group was 70.0%（28/40）, which was significantly higher than control group’s 47.5%（19/40）, （χ2 =4.178, P〈0.05;disease control rate was 87.5% （35/40）, which was higher than control group’ s 67.5% （27/40）,（χ2 =4.588, P〈0.05）.Before treatment, research group and control group’ s KPS scores were （56.50 ±5.80） points and （56.25 ±6.28） points, KPS score after treatment was （66.50 ±9.49） points and （68.25 ±8.44） points, which were better than before treatment in both of the two groups （ t =-6.817, t =-5.942, P〈0.05）; compared with before treatment, after treatment’ s CEA, CA125, CA199 decreased significantly （research group：t =6.593, t =2.189, t =1.606, P〈0.05;control group：t =6.125, t =2.099, t =1.897, P〈0.05）, but no significant differences were found be-tween before and after treatment in both of the two groups （before treatment：t =0.213, t =-0.973, t =0.103, P〉0.05;after treatment：t =-0.422, t =-0.945, t =0.872, P〉0.05）;Research group’s gastrointestinal reactions was 17.5%（7/40）,which was lower than control group’s 37.5%（15/40）with a statistically significant difference（χ2 =4.013, P〈0.05）.Conclusion Docetaxel chemotherapy for treated peritoneal perfusion in elderly patients with gastric and malignant asci-tes revealed good effect, it can improve the quality of life and reduce the tumor markers level, and release the adverse reactions.
出处
《疑难病杂志》
CAS
2015年第5期487-490,共4页
Chinese Journal of Difficult and Complicated Cases
关键词
多西紫杉醇
腹腔热灌注化疗
胃癌
恶性腹水
Docetaxel
Intraperitoneal hyperthermic perfusion chemotherapy
Gastric cancer
Malignant ascites
