摘要
目的 观察奥沙利铂、多西他赛与替吉奥三药方案治疗晚期胃癌的临床疗效和不良反应。方法 65例经病理学证实的晚期胃癌患者,接受奥沙利铂、多西他赛与替吉奥三药联合方案治疗。奥沙利铂85 mg/m2 d1,多西他赛75 mg/m2 d2,替吉奥80 mg/（m2？d）每日分2次口服d1~14。每21 d为一周期。连续2周期后进行影像学检查和实验室检查评价疗效和不良反应。结果 65例患者完成至少2周期化疗,其中61例可评价疗效。完全缓解（CR）0例,部分缓解（PR）23例,稳定（SD）29例,进展（PD）9例。总有效率（ORR）为23/61（37.7%）,临床获益率（DCR）为52/61（85.3%）。化疗常见不良反应主要有骨髓抑制,胃肠道反应,神经损伤。其中,Ⅲ~Ⅳ级血液学毒性发生率为19/61（31.2%）。全组无因严重不良反应终止治疗者,无治疗相关性死亡。结论 奥沙利铂、多西他赛与替吉奥三药方案治疗晚期胃癌的近期疗效好,毒性反应可以耐受,值得进一步推广。远期疗效尚待进一步研究。
Objective To assess the efficacy and toxicity of regimen consisting oxaliplatin, docetaxel and S-1 for advanced gastric cancer. Methods 65 cases of patients with advanced gastric cancer treated with the regimen of oxaliplatin, docetaxel and S-I. Chemotherapy regimens： oxaliplatin and docetaxel were given intravenously at a dose of 85 mg/m^2 dl and 75 mg/m^2 dl; S-1 80 mg/m^2 daily points 2 times oral dl-14. This regimen was repeated every 21 d. The efficacy and toxicity were evaluated after completion of 2 cycles at least. Results The 65 patients no cases of complete remission. 23 cases achieved a partial response. 29 cases had stable disease. And 9 cases showed progressive disease. The overall response rate of this series was 37.7%. And overall disease control rate was 85.5%. The major toxicities were leukocytopenia, nausea, vomiting, peripheral neuritis and alopecia. Among them I]I-IV degree of hematologic toxicity was 31.2%. There were no serious adverse reactions due to termination of treatment. No treatment related death. Conclusion The regimen of oxaliplatin, docetaxel and S-1 is effective and tolerable for advanced gastric cancer. It can be a good choice for advanced gastric cancer.
出处
《中国医药指南》
2015年第12期25-26,共2页
Guide of China Medicine
关键词
晚期胃癌
化疗
奥沙利铂
多西他赛
替吉奥
Advanced gastric cancer
Chemotherapy
Oxaliplatin
Docetaxel
S-1
