摘要
以血脂异常的中、老年人为对象,研究了ApoB基因XbaI和EcoRI多态性对运动调节血脂异常作用的影响。首先,通过运动耐量试验测定血脂异常人群的心脏功能(F.C.),在此基础上制订调脂运动处方。运动强度为50%F.C.~70%F.C.,每次运动持续时间为30min^60min,观察了实施调脂运动处方后血脂异常人群的血脂改善情况,探讨了与血脂异常有关的ApoB基因多态性对有氧运动调节血脂作用的影响。研究发现,ApoB基因EcoRI与XbaI多态性会影响运动对血脂异常的调节作用,表现在运动干预后血清HDL-C水平变化上的差异。血脂异常人群中,携带EcoRI位点的E2E2基因型和XbaI位点的X1X2基因型者经有氧运动干预后,血清HDL-C水平显著改善;携带E1E1基因型、E1E2基因型与X1X1基因型者经有氧运动干预后,血清HDL-C水平无明显改善。血脂异常人群中,同时携带E2E2基因型与X1X1基因型者,有氧运动干预后血清HDL-C显著改善;但同时携带E1E2基因型与X1X1基因型者,有氧运动干预后血清HDL-C水平无改善。该结果揭示,血脂异常人群ApoB基因EcoRI与XbaI位点基因型的差异将影响有氧运动的调脂效果。
This paper studies the effects of EcoRI and XbaI polymorphisms of apolipoprotein B gene on the treatment of dyslipidemia through exercise. The subjects were middle-aged people with dyslipidemia. First of all, the cardiac functional capacity （F. C. ） was measured using gra- ded exercise testing. After that, the exercise prescription was drawn up. The exercise intensity was at the level of 50%-70% F. C. and the duration were 30 to 60 minutes. The improvement in serum lipids profile after applying exercise prescription was observed and the effect of apolipoprotein B gene polymorphism on the treatment of dyslipidemia through exercise inter- ventions was probed into. The results show that EcoRI and XbaI polymorphisms of apolipopro- tein B gene can influence the effect of exercise interventions on dyslipidemia treatment, which mainly appears as the difference in the improvement of serum HDL-C level after exercise inter- ventions. For those individuals with E2 E2 or X1 ？（2 genotypes, their serum HDL-C level im- proved after aerobic exercise interventions. However, there was no change in serum HDL-C level of those individuals with E1 E1 , E1 Fe or X1 X1 genotypes. For those individuals with both Fe E2 and X1 X1 genotypes, aerobic exercise interventions still can improve serum HDL C level. Nevertheless, for those individuals with both E1 E2 and X1 X1 genotypes, aerobic exercise inter- ventions can not make an improvement in serum HDL-C level. These results designate that the differentiations of EcoRI and XbaI polymorphisms of apolipoprotein B will result in different effects of exercise interventions on blood lipids.
出处
《体育科学》
CSSCI
北大核心
2015年第5期38-47,共10页
China Sport Science
基金
国家科技支撑计划课题(2013BAI06B05)
国家体育总局重点研究领域课题(2014B012)
关键词
血脂异常
有氧运动
中老年
载脂蛋白B基因多态性
dyslipidemia
aerobic exercise
middle-age
a poli poprotein B gene pol ymorphisms
