摘要
目的 探讨PET-CT检查在多发性骨髓瘤（MM）分期中的意义,分析PET-CT检查结果与实验室检查指标的相关性.方法 收集新疆维吾尔自治区人民医院血液科2007年3月至2014年2月收治的初诊MM患者78例,平均年龄61.24岁,治疗前检测血红蛋白、清蛋白、βr微球蛋白（β2-M）及乳酸脱氢酶的水平;同时行PET-CT检查,测量脊柱、骨盆、肋骨的最大标准摄取值（SUVmax）,每例患者取其平均SUV,并计数每例患者PET-CT检出的病灶数,观察平均SUV及病灶数在不同分期患者中有无差异.观察平均SUV、病灶数与血红蛋白、清蛋白、β2-M及乳酸脱氢酶的关系.结果 所有患者按ISS分期分为3期,Ⅰ期患者（10例）平均SUV值为1.84±0.28,Ⅱ期患者（45例）为3.74±0.42,Ⅲ期患者（23例）为6.02±0.93,各期间SUV值差异有统计学意义（均P＜0.05）,平均SUV值与β 2-M（r=0.862,P＜ 0.001）、乳酸脱氢酶（r=0.592,P＜0.001）呈正相关,与清蛋白（r=-0.762,P＜0.001）、血红蛋白（r=-0.685,P＜0.001）呈负相关.患者按病灶数≤3个和＞3个划分,两组低血红蛋白、高乳酸脱氢酶、高βrM患者比例差异有统计学意义（P＜0.05）.结论 PET-CT在一定程度上反映肿瘤负荷,对骨髓瘤的分期有指导意义,有助于制定个体化的治疗方案.
Objective To investigate the staging significance of PET-CT in multiple myeloma,and to observe the relationship between baseline PET-CT and clinical parameters in multiple myeloma.Methods 78 cases newly diagnosed MM patients were selected from the Department of Hematology,the Xinjiang Uygur Autonomous Region people＇s Hospital from March 2007 to February 2014,with average age 61.24 years old.The levels of hemoglobin,albumin,beta 2 microglobulin and lactate dehydrogenase were detected before the treatment.PET-CT was performed to measure SUVmax in the spine,pelvis and rib with an average of the SUVmax in each case,and the number of FDG-avid focal lesions in every patient was counted.The difference of the SUVmax or FLS in different stages and the relationship between SUVmax or FLS and clinical parameters in MM were observed.Results All the patients were divided into 3 stages depending on ISS staging.The average SUV values in 10 cases of stage Ⅰ,45 cases of stage Ⅱ and 23 cases of stage Ⅲ were 1.84±0.28,3.74±0.42 and 6.02±0.93,respectively,and SUV values was significantly different among different groups （P 〈 0.05）.SUV values were positively correlated with levels of beta 2 microglobulin （r =0.862,P 〈 0.001） and lactate dehydrogenase （r =0.592,P 〈 0.001）,and negatively correlated with albumin （r =-0.762,P 〈 0.001） and hemoglobin levels （r =-0.685,P 〈 0.001）.The number of lesions had a correlation with low hemoglobin,high lactate dehydrogenase and high beta 2 microglobulin （P 〈 0.05）.Conclusion PET-CT can reflect tumor burden to some extent,and has the guiding significance for MM stage,which contributes to developing individualized treatment programs.
出处
《肿瘤研究与临床》
CAS
2015年第4期250-252,共3页
Cancer Research and Clinic
关键词
多发性骨髓瘤
PET-CT
分期
Multiple myeloma
Positron emission tomography-computed tomography
Stage
