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宫颈上皮内瘤变组织中P16蛋白表达与HR—HPV病毒载量的相关性研究 被引量:5

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摘要 【目的】探讨宫颈上皮内瘤变(CIN)组织中P16蛋白表达与高危型人乳头状瘤病毒(HR‐HPV)病毒载量的相关性。【方法】选取CIN病例135例为观察组,同时选取正常宫颈组织31例为对照组,采用免疫组织化S‐P二步法检测两组 P16蛋白表达,采用第二代杂交捕获试验法检测 HR‐HPV病毒载量,比较两组HPV‐DNA病毒载量阳性率和 P16蛋白高表达率的差异,分析二者相关性。【结果】观察组P16蛋白高表达率和 HR‐HPV病毒载量阳性率分别为58.5%、68.9%,均明显高于对照组(0.0%,16.1%),其差异均有统计学意义( P<0.01),且观察组高表达率和阳性率随着病变级别的增高而逐渐升高;HR‐HPV病毒载量阳性率与P16蛋白高表达率呈正相关性( P <0.05)。【结论】CIN 组织P16蛋白表达与 HR‐HPV病毒载量阳性率明显增高,且两者密切相关。
作者 祝莉
出处 《医学临床研究》 CAS 2015年第4期804-806,共3页 Journal of Clinical Research
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