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十一酸睾酮联合血府逐瘀口服液治疗少弱精子症的临床研究 被引量:1

Clinical research of testosterone undecanoate and Xuefu Zhuyu oral liquid in treating patients with oligoasthenospermia
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摘要 目的:观察十一酸睾酮联合血府逐瘀口服液治疗少、弱精子症患者的疗效。方法:采用随机对照的临床研究,将确诊的150例患者随机分为对照组(70例)和治疗组(80例)。对照组服用Vit E,100mg/次,2次/d;治疗组服用十一酸睾酮胶丸治疗,每次40mg,2次/d,同时联合血府逐瘀口服液,每次10m L,3次/d。两组治疗3月后,分别检测精液质量(精液量、精子浓度、前向运动精子、精子DFI)及妊娠率。结果:有140例患者完成了临床研究,治疗组在精液量、精子浓度、前向运动精子、精子DFI方面较用药前均有显著的改善(P<0.05),并在改善精子浓度、前向运动精子、精子DFI及妊娠率方面,疗效优于对照组(P<0.05)。结论:十一酸睾酮联合血府逐瘀口服液可显著改善少、弱精子症患者的精子质量和妊娠率,可以作为临床治疗男性不育症的安全有效方案。 Objectives:To observe the efficacy of testosterone undecanoate and Xuefu Zhuyu oral liquid in the treatment of oligoasthenospermia.Methods:In the randomized controlled study,150 diagnosed infertile men with oligoasthenospermia were divided into two groups including the control group (70 cases)and the treatment group (80 cases).The control group received VitE,100mg once,bid.The treatment group was given testosterone undecanoate,40mg,bid,with Xuefu Zhuyu oral liquid,10 ml,tid.After the treatment of 3 months,the semen volume,spermatozoa density,prorsad spermatozoa rate,spermatozoa DFI,and pregnancy rate of the two groups were compared.Results:A total of 140 patients accomplished the clinical trial.In the treatment group,the index of semen volume,spermatozoa density,prorsad spermatozoa rate,spermatozoa DFI,were obviously improved com-pared to pre -treatment (P〈0.05).Besides,it was obviously ameliorated of spermatozoa density,prorsad sperma-tozoa rate,spermatozoa DFI,and pregnancy rate compared to the control group (P〈0.05).Conclusion:Testos-terone undecanoate and Xuefu Zhuyu oral liquid can evidently improve the seminal quality and pregnancy rate of oli-goasthenospermia patients,which can serve as a safe and effective clinical treatment method for male infertility pro-gram.
出处 《中国性科学》 2015年第5期91-93,共3页 Chinese Journal of Human Sexuality
关键词 少弱精子症 十一酸睾酮 血府逐瘀口服液 微循环 Oligoasthenospermia Testosterone undecanoate Xuefu Zhuyu oral liquid Microcir-culation
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参考文献15

  • 1宋春生,赵家有.《EAU男性不育症指南(2012年版)》解读[J].中国性科学,2012,21(10):13-16. 被引量:52
  • 2Foresta C, Bettella A, Spolaore D, et 81. Suppression of the high en- dogenous levels of plasma FSH in infertile men are associated with improved Sertoli cell function as reflected by elevated levels of plasma inhibin B . Hum Reprod, 2004, 19(6): 1431 -1437.
  • 3Giwercman A, Richthoff J, Hjollund H, et al. Correlation between sperm motility and sperm chromatin 'ucture assay parameters. Fer- lil Steril, 2003, 80 (6) : 1404-1412.
  • 4郑新民,郑航,张林.雄激素对精子发生的影响[J].医学新知,2008,18(1):7-9. 被引量:5
  • 5Yildirim ME, Koc A, Kaygusuz IC, et al. The association between serum follicle - stimulating hormone levels and the success of micro- dissection testicular sperm extraction in patients with azoospermia. Urol J, 2014, 11(4) : 1825 -1828.
  • 6秦达念,方廉.睾丸内细胞间的相互作用[J].国外医学(内分泌学分册),1995,15(3):128-131. 被引量:3
  • 7Rebourcet D, O'shaughnessy PJ, Monteiro A, et al. Sertoli cells maintain leydig cell number and pefitubular myoid cell activity in the adult mouse testis . Plos One. 2014, 9(8) : E105687.
  • 8Cooke PS, Young P, Cunha GR. Androgen receptor expression in developing male reproductive orgaos. Endocrinology, 1991,128 ( 6 ) : 2867 - 2873.
  • 9Franeomano D, Lenzi A, Aversa A. Effects of five - year treatment with testosterone undecanoate on metabolic and hormonal parameters in ageing men with metabolic syndrome . Int J Endocrinol, 2014 (12) : 527470.
  • 10何学酉,李钢,张旭,姜辉,赵连明,戴东曦,谢毅.小剂量雄激素治疗少弱精子症的临床研究[J].中国男科学杂志,2009,23(12):42-45. 被引量:15

二级参考文献101

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  • 1Baker K,Mc Gill J,Sharma R,et al.Pregnancy after varicocelectomy:Impact of postoperative motility and DFI.Urology,2013,81(4):760-766.
  • 2Baklouti-Gargouri S,Ghorbel M,Mahmoud AB,et al.Mitochondrial DNA mutations and polymorphisms in asthenospermic infertile men.Molecular Biology Reports,2013,40(8):4705-4712.
  • 3Shen S,Wang J,Liang J,et al.Comparative proteomic study between human normal motility sperm and idiopathic asthenozoospermia.World Journal of Urology,2013,31(6):1395-1401.
  • 4Shang H,Hyun KA,Kwon MH,et al.Microfluidic sorting of fluorescently activated cells depending on gene expression level.Electrophoresis:The Official Journal of the International Electrophoresis Society,2013,34(22-23):3103-3110.
  • 5Paulson DF,Wacksman J.Clomiphene citrate in the management of male infertility.The Journal of Urology,1976,115(1):73-76.
  • 6Xu S,Jia ZF,Kang C,et al.Upregulation of SEPT7 gene inhibits invasion of human glioma cells.Cancer Investigation,2010,28(3):248-258.
  • 7Fried L,Behr S,Jung K,et al.Identification of a target gene and activating stimulus for the Ypd A/Ypd B histidine kinase/response regulator system in Escherichia coli.Journal of Bacteriology,2013,195(4):807-815.
  • 8江莉,李慕军,覃莉.不同类型精子发生障碍与精子TEKT5基因mRNA的表达相关性研究[J].中国妇幼保健,2012,27(32):5140-5143. 被引量:2
  • 9莫毅,梁方方,谢伟,王娟,叶健,谢丹尼.线粒体ATPase-6基因多态性与男性精子活力的关系[J].山东医药,2013,53(17):15-17. 被引量:3
  • 10李玉山,吉晓菲,王全先,杨险峰,潘周辉,胡耀龙.特发性弱精子症患者精子中TCTE3的表达[J].郑州大学学报(医学版),2014,49(1):83-85. 被引量:9

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