摘要
目的:比较舌下含服米索前列醇与注射缩宫素在预防阴道分娩产后出血的效果。方法:将500名经阴道分娩的的产妇随机分为两组,一组分娩后舌下含服米索前列醇400μg,另一组分娩后肌肉注射缩宫素10 IU,比较两组在产后出血的发生率、产后出血量、24h血红蛋白下降水平、副作用的发生率、第三产程、需要输血人数。结果:米索前列醇组患者的产后出血的发生率、产后失血量和缩宫素组没有显著差异(7.2%和6.4%,P=0.81;148.21mL和143.02mL,P=0.32),但是米索前列醇组在患者发生严重寒颤和发热的发生率比缩宫素组偏高(严重寒颤:3.6%和0.0%,P=0.004;发热:1.6%和0.4%,P=0.04),有统计学差异。结论:舌下含服米索前列醇400ug与肌肉注射缩宫素10 IU在预防产后出血的效果相当,但舌下含服米索前列醇见效快,用法方便。
Objectives：To compare the effect of sublingual misoprostol with intramuscular oxytocin for pre-vention of postpartum hemorrhage （PPH）in vaginal birth.Methods：500 women without risk of PPH were random-ly divided into two groups.One group was allocated to receive 400 ug of misoprostol sublingually and the other group 10 IU of oxytocin intramuscularly.The incidence of PPH,the amount of PPH,drop in hemoglobin level in 24 hours,the incidence of adverse effects,duration of third stage and need for blood transfusion were compared.Re-sults：Incidence of postpartum hemorrhage and postpartum blood loss in the misoprostol group were similar to those in the oxytocin group （7.2% versus 6.4%,P =0.81;148.21 mL versus 143.02 mL,P =0.32）.Shivering and pyrexia were encountered more often in the misoprostol than in the oxytocin group （shivering：3.6% versus 0.0%, P =0.004,pyrexia：1.6% versus 0.4%,P =0.04）.Conclusion：The efficacy of 40 ug of misoprostol adminis-tered sublingually was equivalent to that of 10 units of oxytocin given intramuscularly for prevention of PPH in vagi-nal delivery.But the effect of misoprostol administered sublingually is faster than oxytocin given intramuscularly, which is more convenient.
出处
《中国性科学》
2015年第5期99-101,共3页
Chinese Journal of Human Sexuality
基金
湖北省教育科学"十二五"规划课题资助项目(2013B308)
关键词
产后出血
米索前列醇
缩宫素
副作用
Postpartum hemorrhage
Misoprostol
Oxytocin
Adverse effects
