摘要
目的 探讨血清超敏C-反应蛋白（Hs-CRP）水平变化与急性脑出血（ICH）间的关系.方法 以30例健康体检者为对照组,将72例初发ICH患者根据头颅CT或MRI检查结果,运用多田氏计算法测定出血量,按出血量分为少量出血组（＜20ml）、中量出血组（20～30ml）和大量出血组（＞30ml）,采用免疫比浊法检测3组患者血清Hs-CRP浓度,分析不同时间患者血清Hs-CRP水平与出血量的关系及其血清Hs-CRP水平与预后的关系.结果 在不同时期3组患者血清Hs-CRP水平均高于对照组,差异均具有统计学意义（均P＜0.05）;ICH患者随着出血量增大,血清中Hs-CRP水平也越高;3组患者血清中Hs-CRP水平第3天较24小时内有上升趋势（均P＜0.05）,第7天与第3天比较略有下降（P＜0.05）,第12天与第7天比较亦有下降趋势（P＜0.05）;经直线相关分析,血清Hs-CRP水平与预后好转率呈显著负相关（r=0.69,P＜0.01）.结论 ICH患者血清Hs-CRP水平的动态变化间接反映了机体炎症反应、脑水肿严重程度,血清Hs-CRP水平越高其预后也越差.因此,血清Hs-CRP水平可作为判断患者病情变化和预后的观测指标.
Objective To observe the cerebral hemorrhage （ICH） patients with serum hypersensitive C - reactive protein （Hs CRP） level changes and explore the relationship of it with cerebral hemorrhage and the relationship between the prognosis of cerebral hemorrhage. Methods The control group was 30 cases of healthy check-up. The observation group was 72 patients with incipient cerebral hemorrhage. According to head CT or MRI examination results using Chef calculation method to determine the amount of bleeding. According to the amount of bleeding divided into bleeding group （~20 ml）, amount of bleeding during group （20 ml~ 30 ml） and massive hemorrhage group （~30 ml）. Immune turbi- dimetric method is used to detect the three groups of patients serum Hs - CRP concentration. Analysis of different time of the patient＇s serum Hs - the relationship and in patients with serum CRP level and the bleeding Hs CRP levels and the re- lationship between the prognosis of patients. Results The Hs-CRP serum levels of three groups of patients in different periods were higher than that in the control group （P〈0.05）. The haemorrhage amount and levels of Hs-CRP of pa- tients with cerebral hemorrhage was larger, serum Hs-CRP level in the thirdly day of the three groups increased com- pared with that of the first day （P〈0.05）, which at seventh day slightly decreased compared with that at the third day （P〈0.05）. The hs-CRP Serum levels and prognosis had significant negative correlation（r= 0.69, P〈0.01）. Conclusion The dynamic changes of the serum Hs - CRP levels in patients with indirectly reflects the body＇s inflammatory re sponse, cerebral edema extent. The higher of the hs - CRP serum levels the worse prognosis. So the serum Hs - CRP lev- el can be as an indicator that estimate the prognosis of patients condition change and observation.
出处
《西部医学》
2015年第6期882-884,共3页
Medical Journal of West China
关键词
脑出血
超敏C-反应蛋白
脑水肿
炎症反应
Cerebral hemorrhage
High-sensitivity C-reactive protein
Encephaledema
Inflammatory response
