摘要
目的探讨清火栀麦片的稳定性。方法采用高效液相色谱法测定清火栀麦片在一定的温度和湿度下放置不同时间后,其主要有效成分栀子苷、穿心莲内酯和脱水穿心莲内酯的含量。结果经加速稳定性试验,放置6个月之后,栀子苷含量无显著差异,穿心莲内酯和脱水穿心莲内酯含量则均下降。结论该方法测定结果准确,精密度和重现性较好,清火栀麦片质量较为稳定。
Objective To investigate the stability of Qinghuozhimai Tablets. Methods Using high performance liquid chromatography determination of Qinghuozhimai Tablets placed at different times in a certain temperature and humidity,the content of its main effective component geniposide,andrographolide and dehydroandrographolide. Results Through accelerated stability test,after storing for 6 months,the content of geniposide had no significant difference and the contents of andrographolide and dehydroandrographolide were descended. Conclusion The method was accurate,precise and reproducible. The quality of Qinghuozhimai Tablets was stable.
出处
《药学研究》
CAS
2015年第5期285-288,共4页
Journal of Pharmaceutical Research
