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间充质干细胞治疗GVHD的机制与临床研究进展 被引量：4

Editorial comment to mesenchymal stem cells into graft-versus-host disease
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摘要 近年来,间充质干细胞（MSCs）的临床应用研究成为细胞治疗的热点,MSCs具备干细胞的特性及多向分化潜能;可向炎症或损伤部位定向迁移并抗炎或修复损伤组织;还因其低免疫原性、较强的免疫调节及抗微生物作用而成为临床应用的理想选择〔1〕。动物试验与部分临床研究已证实MSCs与造血干细胞（HSC）共移植,有助于造血和免疫功能重建,并可抑制异基因造血干细胞移植（allo-
作者 肖扬
机构地区 广州军区广州总医院血液科细胞生物治疗与研究中心
出处 《临床血液学杂志》 CAS 2015年第3期374-379,共6页 Journal of Clinical Hematology
基金 全军医学科学技术研究"十二五"重点课题(No:BWS11J071) 广东省自然科学基金重点课题(No:2014A030311006) 广州市健康医疗协同重大疾病干细胞治疗技术创新与临床转化专题(No:201400000003-1 No:201400000003-4)
关键词 间充质干细胞 免疫抑制 移植物抗宿主病 细胞治疗 mesenchymal stem cells immunosuppression graft-versus-host disease cellular therapy
分类号 R392 [医药卫生—免疫学]
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参考文献36

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二级参考文献32

  • 1何广胜 ,邵宗鸿 ,和虹 ,刘鸿 ,白洁 ,施均 ,曹燕然 ,涂梅峰 ,孙娟 ,贾海蓉 ,杨崇礼 .重型再生障碍性贫血患者骨髓中辅助性T细胞亚群数量及功能的变化[J].中华血液学杂志,2004,25(10):613-616. 被引量：35
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  • 10Glennie S,Soeiro I,Dyson PJ,et al.Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells.Blood.2005;105(7):2821-2827.

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临床血液学杂志
2015年 第3期

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