摘要
目的:探讨血清胱抑素C(CysC)水平在急性冠脉综合征(ACS)中的预测价值。方法:选取132例行冠状动脉造影检查及治疗的ACS患者[不稳定型心绞痛(UA)组42例,非ST段抬高型心肌梗死(NSTEMI)组46例,ST段抬高型心肌梗死(STEMI)组44例],同期选取41名冠状动脉造影检查阴性者作为对照组。收集并分析一般临床资料并检测CysC,计算Gensini积分。结果:(1)各组间CysC水平比较,差异有统计学意义(F=52.732,P<0.001)。(2)UA及NSTEMI患者CysC水平与冠脉Gensini积分呈正相关。(3)多因素Logistic回归分析显示,高龄、吸烟史、CysC水平升高,高密度脂蛋白水平降低是ACS的影响因素。结论:CysC水平升高是ACS的危险因素,检测CysC对冠脉病变狭窄程度的判断有指导意义。
Objective： To investigate the predictive capability of cystatin C（CysC）among patients with acute coronary syndrome（ACS）.Methods： A total of 132 subjects with ACS examined by coronary angiography（CAG） were consecutively enrolled and further divided into unstable angina（UA, n =42）, non-ST segment elevated myocardial infarction（NSTEMI, n =46）and ST segment elevated myocardial infarction（STEMI, n=44）. Forty-one subjects whose CAG results were negative were enrolled in case-control group. The clinical data were collected during hospitalization and CysC was measured as well. All Gensini scores were evaluated. Results：（1） Statistical differences were found in CysC levels in each group（F=52.732,P〈0.001）.（2） Positive correlation was detected between CysC and Gensini score in UA and NSTEMI patients.（3）Logistic regression analysis showed that the factors affecting ACS were enhanced CysC, smoking, advanced age and decreased high-density lipoprotein cholesterol. Conclusion：The level of serum CysC is correlated with the degree of severity in ACS, and it is a risk factor for ACS.
出处
《天津医科大学学报》
2015年第3期189-192,共4页
Journal of Tianjin Medical University
