摘要
目的：探讨母亲孕早期精神刺激与子代先天性心脏病（CHD）的关系。方法：抽取2012年1月～2014年1月在湖北省武汉市区级妇幼保健机构进行CHD免费筛查、通过常规的听诊及超声心动图筛出、并经市级以上医院确诊的201例CHD患儿为病例组,按照年龄、性别及社区配对选择402例健康婴儿为对照组。用Epi Data 3.1软件录入数据,用SPSS 22.0软件进行单因素和多因素分析。结果：对母亲孕早期精神刺激进行单因素分析,结果显示：孕早期精神刺激与子代CHD的发生有一定关联（χ2=21.6866,P〈0.000 1,OR=9.716,95%CI：3.731～25.299）;多因素分析结果显示：孕早期精神刺激（P=0.0038,OR=5.986,95%CI：1.781～20.118）是CHD的危险因素之一。结论：孕早期精神刺激对子代CHD的发生影响较大。加强围孕期保健、避免负性事件的刺激、让孕母心情保持舒畅可在一定程度上减少CHD的发生。
Objective： To explore the relationship between maternal mental stimulation during the first trimester of pregnancy and congenital heart diseases（ CHD） of the infants. Methods： A total of 201 CHD infants were selected as case group,all the infants received CHD screening in Maternal and Child Health Care Institutions at district level in Wuhan city from January 2012 to January 2014,and they were screened out by conventional auscultation and echocardiography,finally,they were diagnosed definitely in the hospitals above city level.A total of 402 healthy infants were selected as control group according to age,gender and community. The data was input by Epi Data 3. 1software,SPSS 22. 0 software was used to conduct univariate and multivariate analysis. Results： Univariate analysis of maternal mental stimulation during the first trimester of pregnancy showed that maternal mental stimulation during the first trimester of pregnancy was correlated with onset of CHD of the infants to a certain extent（ χ2= 21. 6866,P 〈0. 000 1,OR = 9. 716,95% CI： 3. 731- 25. 299）; multivariate analysis showed that maternal mental stimulation during the first trimester of pregnancy（ P = 0. 0038,OR = 5. 986,95% CI： 1. 781- 20. 118）was one of risk factors of CHD. Conclusion： Maternal mental stimulation during the first trimester of pregnancy has a great impact on CHD of infants. Strengthening periconceptional care,avoiding negative events,and making maternal mood keeping comfortable can reduce the occurrence of CHD to a certain extent.
出处
《中国妇幼保健》
CAS
2015年第16期2596-2598,共3页
Maternal and Child Health Care of China
基金
湖北省人口和计划生育委员会资助项目〔JS-20130020〕
关键词
先天性心脏病
孕产妇
精神刺激
Congenital heart disease
Pregnant woman
Mental stimulation
