摘要
目的:探究甲状旁腺激素(PTH)及血清钙(Ca)水平与脓毒症患者病情严重程度和预后的关系。方法:选取2010年9月至2014年2月我收治的80例脓毒症患者,根据存活情况分为存活组(38例)和死亡组(42例),根据血Ca水平分为正常血钙组(32例)和低血钙组(48例)。检测患者PTH、Ca水平,采用急性生理和慢性健康评分(APACHE II)评价患者病情严重程度,分析APACHEⅡ评分与PTH、Ca水平的相关性,以及Ca水平与预后的关系。结果:生存组PTH水平及APACHE Ⅱ评分均低于死亡组,血Ca水平高于死亡组,差异均统计学意义(P<0.05);APACHEⅡ评分与血Ca呈负相关(r=-0.581,P<0.05),与PTH水平呈明显正相关(r=0.423,P<0.05);正常血钙组治疗后死亡率为25.00%(8/32),低于低血钙组的66.67%(32/48),差异有统计学意义(x2=13.333,P<0.05)。结论:PTH及Ca水平与脓毒血症患者病情严重程度有显著关系,低血Ca提示患者预后差。
Objective： To explore the relationship between parathyroid hormone（PTH）, serum calcium（Ca） and disease severity,prognosis of sepsis patients. Methods： 80 cases of sepsis patients were treated in our hospital between September 2010 and February2010, which were divided into survival group（38 cases） and death group（42 cases） according to the survival situation, and were divided into normal calcium group（32 cases） and low calcium group（48 cases） according to the Ca level. The PTH and serum Ca level were detected, the disease severity was evaluated using the acute physiology and chronic health score（APACHEⅡ）. Analyzed the correlation between APACHE Ⅱ score and PTH, serum Ca level, and the relationship between Ca level and prognosis. Results： The PTH level and APACHE II score of the survival group was lower than that in death the group, the serum Ca level was higher than that of death group,the difference was statistically significant（P〈0.05）; APACHEⅡ score was negatively correlated with serum Ca（r=-0.581, P〈0.05）, while positively correlated with the PTH level（r=0.423, P〈0.05）; After treatment, the mortality rate of normal calcium group was 25%（8/32）,lower than 66.67%（32/48） in the low calcium group, the difference was statistically significant（x2=13.333, P〈0.05）. Conclusion： There is a significant relationship between serum PTH and Ca level and disease severity of sepsis patients, and Low serum Ca indicates a poor prognosis.
出处
《现代生物医学进展》
CAS
2015年第17期3319-3321,共3页
Progress in Modern Biomedicine
