摘要
采用紫外辐照引发共轭亚油酸(CLA)囊泡内聚合反应,获得自交联CLA囊泡.用动态激光光散射(DLS)和冷冻透射电子显微镜(cryo-TEM)等观察自交联CLA囊泡的粒径和形貌变化,结果表明,自交联CLA囊泡的囊泡结构不仅不随温度变化解体,而且表现出明显的温敏膨胀性.自交联CLA囊泡体外释放5-氟尿嘧啶的实验表明其具有温度响应的缓释和控释特性.
Self-crosslinked ufasomes of conjugated linoleic acid （SCLA ufasomes） were obtained from CLA through intravesicular polymerization initiated by mild UV irradiation. Temperature-responsive size and morphology evolutions of the SCLA ufasomes were traced by dynamic light scattering（DLS） and cryo-transmission electron microscope （cryo-TEM）, and it was found that not only the vesicular structure of the SCLA ufasomes was stable but also the vesicular volume was expansive hugely with increasing temperature. In vitro release of 5-Fluorouracil（5-FU） from the SCLA ufasomes was evaluated and the results demonstrated that the drug-loading SCLA ufasomes possessed temperature-responsive sustained and controlled release of 5-FU.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2015年第6期1140-1145,共6页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:21276113)资助~~
关键词
囊泡
自交联共轭亚油酸
形貌
温敏膨胀行为
体外释放
Ufasome
Self-crosslinked conjugated linoleic acid
Morphology
Temperature responsive expansion
In vitro release
