摘要
线粒体功能障碍、AMPK-m TOR信号转导异常可导致糖尿病,脾虚患者存在线粒体功能障碍和AMPK-m TOR信号转导异常。通过健脾来改善线粒体功能和调节AMPK-m TOR信号转导是糖尿病治疗的新思路,将有助于从深层次上理解脾主运化的理论内涵,进一步揭示2型糖尿病胰岛素抵抗状态下脾虚证的本质。
Mitochondrial dysfunction and the abnormalities of AMPK - mTOR signal transduction can lead to type 2 diabetes. Mitochondrial dysfunction and the abnormalities of AMPK - mTOR signal transduction can occur to patients with spleen deficiency. It is a new diabetes treatment idea to improve mitochondrial function and regulate AMPK - mTOR sig- nal transduction by using the treatment of invigorating spleen. It will help us deeper understand the theoretical connotation of＂ spleen controlling transport and transformation＂ and further reveal the essence of spleen deficiency in the state of insu- lin resistance of type 2 diabetes.
出处
《中华中医药学刊》
CAS
北大核心
2015年第6期1346-1348,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金青年科学基金项目(81302877)
