摘要
目的:分析轻度认知障碍患者MR扩散张量成像脑白质变化及其与认知功能障碍之间的相关性。方法:选取2012年7月-2014年7月本院收治的120例轻度认知功能障碍患者作为研究对象,并依照有无深部脑白质缺血将其分为缺血组(n=78)与无缺血组(n=42),同时选取30例健康正常人作为对照组,分别对三组对象行常规磁共振与磁共振扩散张量成像检测,并采用Mo CA(蒙特利尔认知)量表与MMSE(精神状态)评分量表评价纳入对象的精神状态与认知功能,观察三组对象脑白质变化与认知功能障碍之间的相关性。结果:缺血组认知功能评分为(20.29±2.00)分,明显低于未缺血组的(22.11±2.26)分,差异有统计学意义(P<0.05);与未缺血组对比,缺血组额叶ADC值明显上升,FA值显著降低(t=4.228、3.250,P<0.05),顶叶ADC值提升,FA值明显降低(t=2.701、7.532,P<0.05);与对照组比较,未缺血组额叶ADC升高,FA降低(t=7.791、2.874,P<0.05),海马旁回ADC提升,FA下降(t=4.414、5.163,P<0.05)。结论:在MCI患者的临床诊断中,采用MR扩散张量成像检测,可量化分析患者脑白质病变程度,确定其向阿兹海默症转化的可能性,为患者的早期治疗提供指导,值得推广。
Objective：To analyze the changes of cerebral white matter MR diffusion tensor imaging of brain on patients of mild cognitive impairment and the correlation with cognitive dysfunction.Method：120 patients with mild cognitive impairment admitted in our hospital from July 2012 to July 2014 were selected as the study object, in accordance with no deep white matter ischemia were divided into ischemia group （n=78） and non myocardial ischemia group （n=42）, and 30 cases of healthy normal people were selected as control group, the three groups object were respectively given conventional magnetic resonance diffusion tensor imaging and detection, and using MoCA （Montreal cognitive） scale and MMSE （mental state） rating scale evaluated mental status of the object and cognitive function, and cognition of white matter changes and function correlation between barrier in brain of three groups were observed.Result：The function of ischemic group cognitive outcome score of （20.29±2.00）, was significant lower than the ischemia group （22.11±2.26）, the comparison between the two groups had obvious difference （P〈0.05）; compared with non ischemia group, ischemia group frontal ADC were increased, FA value decreased significantly （t=4.228, 3.250,P〈0.05）, parietal ADC value increased, FA value decreased obviously （t=2.701, 7.532,P〈0.05）; compared with the control group, non ischemia group frontal ADC increased, FA decreased （t=7.791, 2.874,P〈0.05）, parahippocampal gyrus ADC upgraded , FA decreased （t=4.414, 5.163, P 〈 0.05）.Conclusion：In clinical diagnosis of patients with MCI, using MR diffusion tensor imaging detection can quantifiable analysis of cerebral white matter lesions level of patients, determine the possibility of conversion to Alzheimer’s disease, and provide guidance for early treatment of patients, is worthy of promotion.
出处
《中国医学创新》
CAS
2015年第15期64-67,共4页
Medical Innovation of China
关键词
脑白质
轻度认知功能障碍
磁共振
MR扩散张量成像
Cerebral white matter
Mild cognitive impairment
Magnetic resonance imaging
Diffusion tensor imaging MR
