摘要
目的 探讨5-羟色胺（5-hydroxytryptamine,5-HT）对卒中后抑郁（post stroke depression,PSD）发生、发展的影响.方法 在万方数据库、中国知网及PubMed中进行检索,纳入2010～2014年关于5-HT系统与PSD相关性研究的文献.根据文献的纳入、排除标准汇总文献,并进行总结、归纳和分析.结果 检索文献258篇,纳入符合标准文献44篇,涉及5-HT水平与PSD关系、5-羟色胺受体（5-hydroxytryptaminereceptor,5-HTR）基因多态性与PSD的关系、5-羟色胺转运体连锁启动区（5-hydroxytryptamine transporterlinked promoter region,5-HTTLPR）基因多态性与PSD的关系、5-HT再摄取抑制剂（SSRIs）对PSD的治疗这四个方面.结论 5-HT水平降低导致PSD的发生,且5-HT水平与PSD的严重程度呈负相关;5-HTR1A、5-HTR2A是PSD发生、发展的相关基因;S等位基因及S/S基因型是PSD发生的易感因素,而L等位基因则是PSD发生的保护因素;SSRIs可通过提高突触间隙5-HT水平,从而改善PSD患者的抑郁症状.在今后的研究中,还需要加大样本量来确认两者关系,以及结合其他因素探讨5-HT与PSD关系.
Objective To investigate the effect of the 5-hydroxytryptamine （5-HT） on the occurrence,development of post-stroke depression （PSD）.Methods The literatures on the relationship between 5-HT and PSD were selected from databases such as Wanfang Data,CNKI and PubMed before in 2010-2014.According to absorption and exclusion criteria of the literature,collect literatures,and summary,induce and analyze on them.Results Search 258 literatures and accept 44 literatures accorded with the criteria,including the relationship between 5-HT and PSD,the relationship between 5-hydroxytryptamine receptor （5-HTR） gene polymorphism and PSD,the relationship between 5-hydroxytryptamine transporter linked promoter region （5-HTTLPR） and PSD,and the treatment of selective serotonin reuptake inhibitors （SSRIs） in PSD.Conclusion Reduced levels of 5-HT lead to the occurrence of PSD,and they had a negative correlation;5-HTR 1 A,5-HTR2A are related genes of PSD;S allele and S/S genotype is susceptible factors of PSD,while the L allele is the protective factors of PSD;SSRIs can increase the level of 5-HT in the synaptic gap so as to improve the depressive symptoms of PSD.In the future,it is necessary to increase the sample size to confirm the relationship between 5-HT and PSD,and combine with other factors to explore the relationship between them.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2015年第4期360-363,共4页
Chinese Journal of Behavioral Medicine and Brain Science
基金
基金项目：山东省自然科学基金（2R2010HL031）
山东省科技攻关项目（2012GGC03047）
