摘要
目的:观测丙泊酚静脉诱导、七氟醚吸入诱导、丙泊酚与七氟醚静吸复合诱导对QT间期的影响。方法:选择2013年1月至2014年1月在广州医科大学附属第一医院择期气管插管全麻下行手术治疗的中青年患者45例为研究对象,根据数字表法随机将患者分为3组:单纯丙泊酚静脉诱导组(P组)、单纯七氟醚吸入诱导组(S组)和丙泊酚七氟醚静吸复合诱导组(PS组),每组各15例。分别于诱导前和诱导后行心电图检查,记录心率、血压、QT间期变化,计算QTc-F。结果:与诱导前相比,P组、S组和PS组诱导后的QTc-F显著延长(P<0.01);3组对QT间期延长的程度比较,差异无统计学意义(P>0.05)。结论:3种诱导方法均有使QT间期延长的趋势,均需谨慎用于术前QT间期延长的患者。
Objective：To observe the effects of propofol intravenous induction, sevoflurane inhalation induction,and propofol intravenous induction combined with sevoflurane inhalation induction on QT interval. Methods： Forty-five young patients, who underwent elective operation with endotracheally intubated general anesthesia in the First Affiliated Hospital of Guangzhou Medical University between January 2013 and January 2014, were included and randomized into single propofol intravenous induction group （ Group P ） , single sevoflurane inhalation induction group （ Group S） ,and propofol intravenous induction combined with sevoflurane inhalation induction group （Group PS）,with 15 cases in each group.Electrocardiography was taken before and after induction. The changes in heart rate, blood pressure, and QT interval were recorded, and the QTc-F was calculated.Results：Compared with the pre-induction, the QTc-F of group P, group S and group PS prolonged significantly after induction （ P〈0.01）; the extent of QT interval prolongation of the three groups did not differ with statistical significance （P〉0.05）.Conclusion：All the three induction methods tend to prolong QT interval, which should be cautiously used for patients who have QT interval prolongation before operation.
出处
《广州医科大学学报》
2014年第5期36-39,共4页
Academic Journal of Guangzhou Medical University
