摘要
目的探讨身体质量指数（BMI）对中国女性乳腺癌患者预后的影响。方法对1699例早期乳腺癌患者进行回顾性分析，评估BMI对无病生存率和总生存率的影响。肥胖定义为BMI≥24。生存分析采用Kaplan-Meier法和Logrank检验，单因素和多因素分析采用Cox风险比例模型。结果1699例乳腺癌均为女性，其中BMI≥24者635例（37．4％），BMI〈24者1064例（62．6％）。与BMI〈24组患者比较，BMI≥24组患者年龄较大（P〈0．001），绝经后患者所占比例多（P〈0．001），淋巴结转移率高（P=0．001），接受保乳术的患者较少（P=0．012）。中位随访时间16个月，BMI〈24组和BMI≥24组乳腺癌患者的16个月无病生存率分别为98．1％和95．0％，差异有统计学意义（P=0．007）；BMI〈24组和BMI≥24组乳腺癌患者的16个月生存率分别为99．4％和98．4％（P=0．004）。多因素分析显示，BMI≥24是影响乳腺癌患者预后的不良因素。结论超重和肥胖是影响中国女性乳腺癌患者预后的不良因素。
Objective Obesity has been shown to be an indicator of poor prognosis for patients with primary breast cancer. The aim of this study was to clarify the effect of obesity on Chinese women with breast cancer. Methods This is a retrospective analysis of 1699 breast cancer patients. We evaluated the effect of body mass index （BMI） on disease-free survival （DFS） and overall survival （OS） in these patients. BMI was obtained before surgery. Obesity was defined as a BMI ≥ 24. Kaplan-Meier analysis and Log rank test were employed to perform survival analysis. The impact of different characteristics on survival was assessed by using Cox proportional-hazards regression model. Results In total 635 （37.4%） patients were obese, while 1 064 （62.6%） were non-obese. Comparing the tumor characteristics in the two groups, the BMI ≥ 24 group showed a higher rate of older age （P〈0.001） , postmenopausal status （P〈0.001） , increased risk of lymph node metastasis （P= 0.001 ） and less chances of accepting breast conservation surgery （P= 0.012）. The median follow-up time was 16 months, and the estimated 16-months DFS was 98.1% for non-obese and 95.0% for obese patients （P=0.007）, the estimated 16-months OS was 99.4% for non-obese and 98.4% for obese patients （P = 0.004 ）. The multivariate analysis indicated that obesity is an independent prognostic factor for OS and DFS in breast cancer patients. Conclusions Our findings suggest that obesity is associated with a poorer outcome in Chinese female patients with breast cancer.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2015年第5期395-399,共5页
Chinese Journal of Oncology
关键词
乳腺肿瘤
身体质量指数
预后
因素分析
统计学
Breast neoplasms
Body mass index
Prognosis
Factor analysis, statistical
