摘要
目的探讨我院儿童社区获得性肺炎(CAP)细菌感染情况及药敏情况,为抗生素的合理使用提供依据。方法以本院2010年1月至2013年12月儿科收治的CAP患儿为研究对象,回顾性分析CAP的病原菌分布和耐药情况。菌株鉴定使用法国梅里埃VITEK32分析仪,用纸片扩散法做药敏试验。结果病原菌以革兰阴性菌为主,前四位分别为肺炎克雷伯杆菌、大肠埃希菌、流感嗜血杆菌和阴沟肠杆菌;革兰阳性菌次之,主要为肺炎链球菌和金黄色葡萄球菌。药敏结果显示,主要革兰阴性菌对头孢吡肟、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦和亚胺培南耐药率较低;主要革兰阳性菌对左氧氟沙星、莫昔沙星和万古霉素耐药率较低。结论了解CAP患儿病原菌分布,有利于在儿童CAP经验性治疗时制定正确的治疗方案。
Objective To explore the distribution and drug susceptibility of the pathogens in pediatric communityacquired pneumonia（ CAP） cases in our hospital and provide basis for rational use of antibiotics. Methods Retrospective analysis was performed to analyze the pathogen distribution and drug resistance in CAP patients admitted in our hospital from Jan. 2010 to Dec. 2013. The identification was done by Bio-Merieux VITEK32; antimicrobial susceptibility test was performed with K-B method. Results Gram-negative bacteria was the predominant pathogenic bacteria; the top four were Klebsiella pneumoniae,Escherichia coli,Haemophilus influenzae and Enterobacter cloacae. Gram-positive bacteria was the second,mainly Streptococcus pneumoniae and Staphylococcus aureus. The resistance rates of main Gram-negative bacteria to Cefepime,Piperacillin / tazobactam,Cefoperazone / sulbactam and Imipenem were lower,while the resistance rates of main Gram-positive bacteria to Levofloxacin,Moxifloxacin and Vancomycin were lower. Conclusion This result would be helpful to choose proper empirical treatment option for pediatric CAP.
出处
《中国微生态学杂志》
CAS
CSCD
2015年第5期581-583,共3页
Chinese Journal of Microecology
关键词
儿童
社区获得性肺炎
病原菌
分布
耐药性
Community-acquired pneumonia
Pathogenic bacteria
Distribution
Drug resistance
