摘要
目的探讨认知障碍简明评价量表（Cog-12）在行为异常型额颞叶痴呆（bv FTD）中的应用价值。方法入组2007年1月至2014年11月CARDS研究登记的75例bv FTD,根据国际行为变异型额颞叶痴呆标准联盟（international behavioural variant ftd criteria consortium,FTDC）分级诊断标准及临床痴呆量表（CDR）评分分为bv FTD-轻度认知障碍组（MCI组）（CDR=0.5,37例）、bv FTD组（CDR=1-3,38例）。同期招募50例社区老年人作为认知功能正常的对照组（NC组）。所有研究对象均完成Cog-12量表、Addenbrooke改良认知评估量表（ACER）、额叶功能量表（FAB）、额叶行为量表（FBI）的测评,并记录各量表完成时间。结果 （1）bv FTD组、MCI组和NC组之间ACE-R,FBI,Cog-12,Cog12-1,Cog12-2量表评估结果均不相同（P〈0.01）,bv FTD组与MCI组MMSE,FAB量表评估结果无差异;（2）3组ACE-R,FAB,FBI,Cog-12量表的评估时间均不相同,差异有统计学意义（P〈0.01）,量表评估时间按耗时长短依次为ACE-R〉FBI〉FAB〉Cog-12;（3）Cog-12,FBI对于MCI患者均有较好的筛查能力,Cog-12量表以8/9分作为分界值时,筛查MCI依据最好,敏感度为78.4%,特异度为92.0%;（4）Cog-12和FBI量表呈显著正相关（r=0.801）,且相关程度优于FBI与FAB相关度（r=-0.737）。结论 Cog-12量表及FBI量表均可有效筛查bv FTD的MCI阶段,与FBI量表比较,Cog-12更方便快捷。
Objective To explore the value of brief cognitive impairment rating scale（Cog-12） in the patients with behavioral variant of frontotemporal dementia（ bv FTD）. Methods Seventy-five patients with bv FTD from January 2007 to November 2014 were enrolled in this study. The patients were divided into mild cognitive impairment group（ CDR =0. 5,n = 37） and probable bv FTD group（ CDR = 1 to 3,n = 38） according to diagnosis criteria of International Behavioural Variant FTD Criteria Consortium and the scores of clinical dementia rating（ CDR）. Fifty community elderly people were enrolled as normal control group. The Addenbrooke＇s Cognitive Examination-revised（ ACE-R）,and Frontal Assessment Battery（ FAB） were applied for evaluating cognitive performances in each group. And Cog-12 scale and Frontal Behavioural Inventory（ FBI） were applied for caregivers of each group. Results（1） MMSE and FAB showed no significant differences between bv FTD group and MCI group,and the scores of ACE-R,FBI,Cog-12,Cog12-2 showed significant differencesbetween three groups（ P〈0. 01）.（ 2） The differences were significant in the time-consumption of scores of ACE-R,FAB,FBI,Cog-12. The time consumption of these scales were ranked as follows： ACE-R FBI FAB Cog-12.（ 3） Both Cog-12 and FBI were able to differentiate bv FTD-MCI from normal controls. The optimal Cog-12 cut-off score of 8 /9 get 78. 4% sensitivity and 92. 0% specificity in distinguishing MCI from normal controls.（4） Significant correlation were observed between Cog-12 and FBI（ correlation coefficient r = 0. 801,P〈0. 01）. And the correlation coefficient was higher than that between FAB and FBI（ correlation coefficient r =- 0. 737,P〈0. 01）. Conclusions Either FBI or Cog-12 scale is a reliable assessment tool suitable to screen patients with bv FTD-MCI. Compared with FBI,Cog-12 scale is more convenient.
出处
《实用老年医学》
CAS
2015年第5期371-374,共4页
Practical Geriatrics
基金
国家自然科学基金资助项目(81471215
81271211
30700248)
江苏省重点实验室开放课题(SJ11KF05)
江苏省社会发展项目(BE2011614)
科技部新药创制重大专项(2012ZX09303005-002
2012ZX09303-003)
