摘要
目的探讨强化他汀治疗对行经皮冠状动脉介入术(PCI)后不稳定型心绞痛(UA)患者的有效性及安全性。方法检测60例高负荷量他汀治疗组,60例常规负荷量他汀治疗组,60例常规治疗组UA患者术前1d和术后1周、1个月、6个月血脂水平、肝肾功能、超敏C-反应蛋白(hs-CRP)和纤维蛋白原(Fg)水平,观察药物的不良反应。结果不同剂量的阿托伐他汀钙在术后1周、1个月、6个月均可降低总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、hs-CRP、Fg水平且服用时间越长效果越显著(P<0.05,P<0.01);高负荷量他汀治疗组与同时间点常规负荷量组和常规治疗组相比差异亦有统计学意义(P<0.05,P<0.01)。高负荷量他汀组服用6个月亦可降低三酰甘油(TG)水平,升高高密度脂蛋白胆固醇(HDL-C)水平(P<0.05,P<0.01)。各组未见严重不良反应。结论强化他汀治疗不稳定型心绞痛临床疗效更显著,安全性良好。
Objective To explore the safety and efficacy of high- load Atorvastatin in patients with unstable angina （UA） after percutaneous coronary intervention （PCI）. Methods The level of blood lipid, hs- CRP, Fg and the function of liver and kidney were detected in sixty patients with high- load Atorvastatin, sixty patients with ordinary- load Atorvastatin and sixty patients with ordinary Atorvastatin one day before PCI and one week, one month and six months after PCI. Adverse drug reaction was also observed. Results Different doses of Atorvastatin could reduce the level of total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C）, hs-CRP and Fg after PCI for one week, one month and six months. The longer the time to take Atorvastatin, the more obvious the effect was （P〈0. 05）. High- load Atorvastatin showed significant difference compared with those in ordinary- load Atorvastatin and ordinary Atorvastatin （P〈0.05）. High- load Atorvastatin used for six months could also reduce the level of triacylglycerol （TG） and heighten the high density lipoprotein cholesterol （HDL-C） （P〈0.05）. There were no serious adverse drug reactions in each group. Conclusion The use of high- load Atorvastatin seems better safety and efficacy in UA patients.
出处
《中国煤炭工业医学杂志》
2015年第5期780-783,共4页
Chinese Journal of Coal Industry Medicine
