摘要
目的探讨双生子胃黏膜组织中白介素(interleukin,IL)-17的表达水平。方法青岛市区的35对双生子接受胃镜检查。单卵(MZ)双生子23对,异卵(DZ)双生子12对。采用免疫组织化学染色的方法检测胃黏膜组织中IL-17的表达水平。结果在MZ和DZ双生子的胃黏膜组织中,IL-17的表达水平相比,差异无统计学意义(P>0.05)。中-重度炎症的胃黏膜组织中IL-17的表达水平明显高于轻度炎症(P<0.01)。MZ和DZ双生子两位成员的胃黏膜组织中,IL-17表达水平一致的分别为7对(30.4%)和4对(33.3%),Kappa系数分别为0.019和0,IL-17表达水平一致性在MZ和DZ双生子中比较,差异无统计学意义(P>0.05)。结论双生子胃黏膜组织中IL-17的表达水平无明显不同,可能受环境因素影响更多。
Objective To investigate the expression of interleukin （IL） -17 in the gastric mucosa in twins. Meth- ods Total 35 pairs of twins living in urban district of Qingdao city were enrolled and accepted gastroscopy. Threr were 23 pairs of monozygotic （MZ） twins and 12 pairs of dizygotic （DZ） twins. The expression of IL-17 in gastric mucosa was detected by immunohistochemistry. Results No significant difference of the expression of IL-17 was observed be- tween MZ and DZ. The expression of IL-17 in gastric mucosa with moderate to severe inflammation was significantly higher than that in mild inflammation （P 〈 0.01 ）. Concordance of the expression of IL-17 in two members of MZ and DZ were 7 （30.4%） and 4 （33.3%） , respectively. The Kappa coefficients were 0. 019 in MZ and 0 in DZ. The con- cordance rate of expression of IL-17 had no significant difference between MZ and DZ （P 〉 0.05）. Conclusion Envi- ronmental factors may exert more influence on the expression of IL-17 in the gastric mucosa in twins.
出处
《胃肠病学和肝病学杂志》
CAS
2015年第5期565-567,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
双生子
胃黏膜
白介素17
遗传
环境
Twins
Gastric mucosa
Interleukin 17
Genetic
Environment
