摘要
目的观察胃肠安丸联合四联疗法治疗儿童幽门螺杆菌感染的临床疗效。方法 2013年1月—2014年8月沈阳市儿童医院收治的幽门螺杆菌感染患儿98例,随机分为对照组和治疗组,每组49例。对照组给予四联疗法治疗,治疗组在四联疗法的基础上口服胃肠安丸。两组均连续治疗14 d。比较两组患儿腹痛、食欲不振、恶心呕吐等临床表现的持续时间、幽门螺杆菌根除率、抗生素相关性腹泻发生率。结果治疗后,治疗组腹痛、食欲不振、恶心呕吐持续时间显著短于对照组,两组比较差异有统计学意义(P<0.05)。对照组和治疗组幽门螺杆菌根除率分别为91.83%、95.91%,两组比较差异无统计学意义。对照组和治疗组抗生素相关性腹泻发病率分别为18.3%、8.1%,两组比较差异有统计学意义(P<0.05)。结论胃肠安丸联合四联疗法治疗儿童幽门螺杆菌感染具有较好的临床疗效,可缓解临床症状,减少抗生素相关性腹泻的发生。
Objective To observe the therapeutic effect of Weichang＇an Pills combined with quadruple therapy in treatment of helicobacter pylori infection in children. Methods Patients （98 cases） with helicobacter pylori infection in Shenyang Children＇s Hospital from January 2013 to August 2014 were randomly divided into control and treatment groups, and each group had 49 cases. The patients in the control group were given quadruple therapy. The patients in the treatment group were po administered with Weichang＇an Pills at the basis of quadruple therapy. Both groups were treated for 14 d. The duration of abdominal pain, loss of appetite, nausea, vomiting, eradication rates of helicobacter pyloii, and incidence of antibiotic associated diarrhea in two groups were compared. Results After treatment, durations of abdominal pain, loss of appetite, nausea, and vomiting were shorter than those in the control group, and there were differences between two groups （P 〈 0.05）. The eradication rates ofhelicobacter pylori in the control and treatment groups were 91.83% and 95.91%, respectively, and there was no differences between two groups. The incidence of antibiotic associated diarrhea in the control and treatment groups were 18.3% and 8.1%, respectively, and there were differences between two groups （P 〈 0.05）. Conclusion Weichang＇an Pills combined with quadruple therapy has the good clinical effect in treatment of helieobacter pylori infection in children, and can alleviate clinical symptoms, while can reduce the occurrence of antibiotic associated diarrhea.
出处
《现代药物与临床》
CAS
2015年第5期577-578,共2页
Drugs & Clinic
关键词
胃肠安丸
雷贝拉唑钠肠溶片:胶体果胶铋胶囊
克拉霉素片
甲硝唑片
幽门螺杆菌
Weichang＇an Pills
Sodium Rabeprazole Enteric-coated Tablets
Colloidal Bismuth Pectin Capsules
Clarithromycin Tablets
MetronidazoleTablets
helicobacter pylori
