摘要
目的：观察围绝经期骨量减少妇女给予钙剂、性激素及健康指导综合干预措施临床效果。方法：以2011年1~12月来本院健康体检及门诊就诊的1600例围绝经期妇女为调查对象,详细询问病史,了解有无月经失调及更年期症状,从中筛查出骨量丢失妇女736例,按照随机数字法随机分为观察组和对照组,每组368例,其中观察组给予钙剂、性激素及健康指导进行综合干预,对照组给予口服钙尔奇D和口服激素替代治疗,1年后复查两组骨密度、性激素变化情况。结果：治疗1年后观察组总有效率（88.3%）高于对照组（71.7%）,差异具有统计学意义（χ2=4.645,P〈0.05）;观察组睾酮（T）及雌二醇（E2）、促卵泡激素（FSH）均显著改善（t=33.0666、12,.2751、11.7441,P均〈0.05）,对照组治疗前后无明显改善（t=0.8488、0.3299、0.5045,P均〉0.05）;两组治疗前后子宫内膜厚度比较无差异（t=0.3507、0.4587,P均〉0.05）;治疗期间观察组发现乳房包块4例,对照组发现2例,经病理证实均为乳房纤维瘤,两组比较无差异（χ2=0.876,P〉0.05）。结论：围绝经期骨量减少妇女通过给予钙剂、性激素及健康指导进行综合干预效果好,安全性高,值得临床应用。
Objective：To explore the effect of comprehensive intervention with calcium supplements,sex hormone and health guidance on the bone mineral density among perimenopausal women.Methods：From January 2011 to December 2011 in our hospital 1600 perimenopausal women were recruited.Their medical history was recorded,and the presence of abnormal menstruation and menopause symptoms were also evaluated.A total of 736 patients who were screened as less bone mineral density were randomly divided into the observation group and the control group（368 cases in each group）.Women in the observation group were given calcium supplements,sex hormone and health guidance while the control group only received drug intervention.One year later the bone mineral density and sex hormone levels of two groups were measured.Results：One year after treatment,the total effective rate in the observation group was 88.3%,significantly higher than that in the control group（71.7%,χ2=4.645,P〈0.05）;Testosterone and estradiol（E2）,follicle stimulating hormone（FSH）level of the observation group were improved significantly（t= 33.0666,12.2751,11.7441,P all〈0.05）,while the control group had no improvement（t=0.8488,0.3299,0.5045,Pall〉0.05）.Endometrial thickness of two groups before and after treatment had no significant difference（t = 0.3507,0.4587,P〉0.05）.During treatment two cases of breast mass in the observation group and one in the control group were found,which were confirmed by pathology as breast fibroma,and there was no significant difference between two groups（χ2= 0.876,P〉0.05）.Conclusion：The comprehensive intervention with calcium supplements,sex hormone combined with health guidance is good and safe,worthy of clinical promotion among perimenopausal women with less bone mineral density.
出处
《中国计划生育学杂志》
2015年第6期399-401,共3页
Chinese Journal of Family Planning
基金
浙江省医药卫生科技计划项目(2011KYB086)
关键词
围绝经期妇女
骨密度
干预
Perimenopausal women
Bone density
Intervention
