摘要
目的探讨氟西汀对急性脑卒中患者超敏C反应蛋白(hs-CRP)和神经功能恢复的影响。方法随机将该院200例急性脑卒中后抑郁患者分为治疗组(112例)和对照组(88例),对照组患者进行神经内科常规治疗,治疗组患者在常规治疗基础上加用氟西汀口服9周。比较2组患者氟西汀治疗前1周和治疗后第3、6、9周的血清hs-CRP水平;同时采用汉密尔顿抑郁量表(HAMD)、巴塞尔(Barthei)指数和改良爱丁堡-斯堪的纳维亚脑卒中量表(MESSS)评定抑郁程度、日常生活能力和神经功能缺损程度。结果氟西汀治疗后,HAMD、MESSS评分较治疗前显著下降,差异有统计学意义(P<0.05);Barthei指数评分显著增高,与对照组比较,差异有统计学意义(P<0.05);患者hs-CRP水平与MESSS评分呈正相关关系。结论氟西汀治疗后患者抑郁状态得到明显改善,神经功能缺损显著降低;hs-CRP水平可在一定程度上反映患者的神经功能。
Objective To observe how the early application of fluoxetine in patients with acute cerebral stroke affects to the hs-CRP and recovery of neurological function. Methods 200 patients with post-stroke depression were divided into fluoxetine treatment group and control group. Control group were gived conventional treatment neurolo- gy,while fluoxetine treatment group were gived oral fluoxetine treatment for 9 weeks based on conventional therapy. In the time 1 week before treatment and 3,6,9 weeks after treatment, hs-CRP levels in serum were measured in the patients, and the degree of depression, ADL and neurological deficits were assessed by HAMD, Barthei index and MESSSResuits After fluoxetine treatment, the score of HAMD, MESSS decreased significantly, compared with those before treatment（P^0.05） ~Barthei index score was significantly higher than the control group（P^0.05） ;hs- CRP levels and MESSS score showed a positive correlation. Conclusion With fluoxetine treatment, patients depres- sion improved, neurological deficit situation reduced, daily living skills improved significantly; hs-CRP levels may be to some extent reflect the patientrs neurological damage.
出处
《检验医学与临床》
CAS
2015年第11期1513-1515,共3页
Laboratory Medicine and Clinic
基金
重庆市卫计委科技计划项目(20143060)
关键词
急性脑卒中
氟西汀
超敏C反应蛋白
神经功能
acute stroker fluoxetine
high sensitive C reactive protein
nerve function
