急性心肌梗死患者外周血嗜酸性粒细胞与超敏C反应蛋白的相关性分析被引量：7

Association of eosinophils in peripheral blood and high sensitive C-reation protein in patients with acute myocardial infarction

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摘要目的探讨急性心肌梗死(AMI)患者外周血中嗜酸性粒细胞(EOS)和超敏C反应蛋白(hs-CRP)的变化,并分析两者的相关性。方法该院2014年1~6月入院治疗的AMI患者50例(AMI组),其中急性ST段抬高型心肌梗死(STEMI)27例,急性非ST段抬高型心肌梗死(NSTEMI)23例;选择同期该院体检健康者50例作为健康对照组。结果 AMI组患者外周血中EOS含量和百分比均显著低于健康对照组,差异有统计学意义(P<0.01);AMI患者的EOS含量、百分比与hs-CRP呈显著负相关(r=-0.254,P<0.05;r=-0.239,P<0.05)。结论AMI患者外周血EOS含量明显减少且与hs-CRP呈负相关,其减少可能与炎性反应有关并在血栓形成中发挥着重要作用。 Objective To observe the changes of eosinopbils in peripheral blood and high sensitive C-reation protein in patients with acute myocardial infarction（AMI）. The aim of this study is to investingate the association of eosinophils in peripheral blood and high sensitive C-reation protein in patients with acute myocardial infarction. Meth- ods The study enrolled 50 acute myocardial infarction patients who were treated in Beijing Tiantan Hospital from January 2014 to June 2014 （27 ST-segment elevation myocardial infarction and 23 non-segment elevation myocardial infarction） and 50 medical individuals who were randomly chosen from the same period of time. Eosinophils counts and percentages and levels of high sensitive C-reation protein in all individuals were determined. Eosinophils counts and percentages and levels of high sensitive C-reation protein between two groups were compared. Association of eo- sinophils in peripheral blood and high sensitive C-reation protein in patients with acute myocardial infarction was e- valuated by Pearson correlation. Results Eosinophils counts and percentages in AMI patients were significantly low- er than those in the control group （P^0.01）. There was a significant inverse correlation between eosinophils counts and percentage and high sensitive C-reation protein （r= -- 0. 254, P^0.05 ; r = -- 0. 239, P^0.05, Pearson correla- tion）. Conclusion Patients with acute myocardial infarction presented decreasing of eosinophils counts and percenta- ges. Eosinophils counts and percentage and high sensitive C-reation protein presented negative correlation. It was pos- sible that Eosinophils took part in the inflammatory response and the Eosinophils played an important role in the thrombosis in patients with acute myocardial infarction.

作者魏欣王德昭陈步星

机构地区首都医科大学附属北京天坛医院心内科

出处《检验医学与临床》 CAS 2015年第11期1547-1549,共3页 Laboratory Medicine and Clinic

关键词嗜酸性粒细胞超敏C反应蛋白急性心肌梗死炎症 eosinophils high sensitive C-reation protein acute myocardial infarction inflammatory

分类号 R541.4 [医药卫生—心血管疾病]

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