摘要
药物成药性在药物开发中至关重要,是药物研究的源头。中药是多成分药物,由于其存在复杂性,在成药性研究中必然面临更大的挑战。本文主要结合中药多成分的化学物质基础本质,提出了研究中药成药性分析的一些观点和思路方法。
Druggability is crucial in pharmaceutical drug development as the source of drug research. Druggability research will face greater challenges because Chinese materia medica （CMM） is the muhieomponent drug. In this paper, ideas and methods of study on CMM druggability were mainly proposed in combination with the chemical material basis of muticomponents of CMM.
出处
《世界科学技术-中医药现代化》
2015年第3期434-437,共4页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委面上项目(81274042):基于口服中药并发多重代谢的药效物质基础体内过程研究方法与关键技术
负责人:刘洋
关键词
多成分药物
中药成药性
多成分配伍
重大新药创制
暴露
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反应
Multicomponent drug, druggability of Chinese materia medica, multicomponent compatibility, major new drug innovation and development, exposure-response relationship
