摘要
目的对房颤患者应用华法令抗凝治疗的影响因素及对象进行相关阐述。方法详细回顾性分析2012年1月—2014年3月来该院进行治疗的房颤患者的临床资料,对患者进行相应治疗,常规包含心率控制、抗血小板,以及运用华法令进行抗凝治疗。按照所使用华法令的起始剂量的不同分成1、2两组,第1组起始剂量为2.5 mg,第2组起始剂量为3.5 mg,治疗第一周每两天监测一次患者的INR。对患者治疗后是否出现血栓进行观察,并对华法令的作用做客观评价。结果该次接受观察的88例患者按照起始剂量分成人数均等的两组,第1组在第三次复查时无1例达到相关指标,其达标平均时间为(13.474.6)d;第二组在第二次复查时无1例达到相关指标,但后期有10例患者在治疗过程中因指标水平超标而停止治疗,平均达标时间(17.656.7)d,差异有统计学意义(P<0.05)。结论华法令对房颤患者有较好的抗凝作用,但有诸多影响因素,起始使用剂量不同,所造成的抗凝效果也有所不同。临床要详细掌握其影响因素,并使用有效方式进行解决。
Objective To observe the effect and influencing factors of atrial fibrillation patients using warfarin anticoagulation therapy. And summarize the nursing countermeasures. Methods a retrospective analysis of our hospital for treatment of 87 cases of atrial fibrillation in patients with clinical data, including the control of ventricular rate, and the use of antiplatelet, warfarin antico-agulant therapy. According to the initial dose of warfarin use is divided into 1, 2 group two, first groups of initial dose is 2.5mg, second groups of initial dose is 3.5mg, first week of treatment every two days to monitor a patient′s INR. About whether there is thrombosis patients after treatment were observed, and the objective evaluation of warfarin. Results The observation of 88 cases of patients received two groups according to the initial dose is divided into equal number, first group 1 cases reach the relevant index in the third review, the average time of the standard （13.47 4.6） second days; group 1 cases reach the relevant index in the second review, but later in 10 patients during the treatment stopped treatment due to exceed the standard level index, average standard time （17.65 6.7） days （P〈0.05）. Conclusion warfarin anticoagulation good effect for patients with atrial fibrillation, But there are many influence factors, the starting dose used different, anticoagulant effect caused by different. Clinical to detailed grasp the influ-encing factors, and puts forward the related countermeasure.
出处
《中外医疗》
2015年第4期130-132,共3页
China & Foreign Medical Treatment
基金
南充市科技计划项目(13A0085)
关键词
房颤
华法令
抗凝治疗
影响因素及对策
Atrial fibrillation
Warfarin
anticoagulation therapy
Influence factors and countermeasures
