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帕利哌酮与氟哌啶醇治疗儿童抽动障碍对照研究 被引量:1

A Control Study of Paliperidone Versus Haloperidol in the Treatment of Tic Disorders in Children
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摘要 目的:比较利帕利哌酮与氟哌啶醇治疗儿童抽动障碍(tic disorders, TD)的疗效及不良反应。方法对该院2012年1月—2014年3月门诊收治的60例儿童抽动障碍患者(年龄8~16岁)随机分成两组,分别给予利帕利哌酮与氟哌啶醇,其中帕利哌酮组30例,氟哌啶醇组30例,疗程8周。分别采用耶鲁抽动症状严重程度量表(Yale Global Tic Severity Scale, YGTSS)和不良反应量表(treatment emergent symptom scale, TESS)对治疗前、治疗后第2、4、8周的治疗效果和不良反应进行评估。结果帕利哌酮组和氟哌啶醇组治疗2周后YGTSS 总分均明显下降,帕利哌酮组治疗2周的YGTSS减分率高于氟哌啶醇组,帕利哌酮组与氟哌啶醇组治疗总体有效率分别为90.0%和66.7%(P〈0.05),帕利哌酮组与氟哌啶醇组不良反应发生率分别为20.0%和76.7%(P〈0.01)。结论帕利哌酮与氟哌啶醇都有效治疗儿童抽动障碍,但帕利哌酮的疗效优于氟哌啶醇,不良反应少,耐受性好,可推荐用于儿童治疗。 Objective To compare the efficacy and adverse reactions between Paliperidone and Haloperidol in the treatment of children with tic disorders(TD). Methods Sixty children of 8-16 years old with tic disorders admitted in our clinic from January 2012 to March 2014 were randomly assigned to Paliperidone group (n=30) and Haloperidol group (n=30), treated by Paliperidone and Haloperidol, respectively, for 8 weeks. The treatment efficacy and adverse reactions were measured by the Yale Global Tic Severity Scale (YGTSS) and the Treatment Emergent Symptom Scale (TESS) at the baseline, week 2, 4 and 8, respectively. Results After 2 weeks of treatment, the total tic scores measured by the YGTSS decreased in both groups, and the rate of YGTSS decreased in Paliperidone group was significantly higher than that in Haloperidol group. The overall rate of effectiveness after 8 weeks’ treatment was 90.0% and 66.7% in Paliperidone group and Haloperidol group, respectively(P〈0.05). The incidence of adverse reactions after 8 weeks’treatment was 20.0% and 76.7% in Paliperidone group and Haloperidol group, respectively(P〈0.01). Conclusion Both Paliperidone and Haloperidol can be used for children with tic disorders. However, Paliperidone may be a promising drug in the treatment of children with tic disorders because of its higher efficacy and less adverse reactions and better tolerance.
出处 《中外医疗》 2015年第10期7-9,共3页 China & Foreign Medical Treatment
关键词 帕利哌酮 氟哌啶醇 儿童抽动障碍 Paliperidone Haloperidol Tic disorders in children
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