摘要
目的:研究舒芬太尼和吗啡在先天性心脏病小儿术后镇痛中的应用,评价其安全性和有效性。方法:选取2011年1月1日至2012年12月31日我院行室间隔缺损修补术的先天性小儿心脏病患儿120例,随机分为小剂量舒芬太尼组(A组)、大剂量舒芬太尼组(B组)、吗啡组(C组)各40例,分析比较三组患儿生命体征、疼痛评分、镇静评分等指标。结果:三组患儿的心率(HR)、平均动脉压(MAP)、血氧饱和度(Sp O2)比较差异无统计学意义(P>0.05);不同时间点各组患儿的HR、MAP、Sp O2比较差异无统计学意义(P>0.05);分组与时间之间无明显的交互作用(P>0.05)。三组的疼痛评分比较B组<A组<C组,差异有统计学意义(P<0.05);三组不同时间点疼痛评分比较差异有统计学意义(P<0.05);分组与时间之间无明显的交互作用(P>0.05)。三组患儿Ramsay评分比较差异无统计学意义(P>0.05),其中A组和B组、A组和C组、B组和C组比较差异均无统计学意义(P>0.05);三组不同时间点Ramsay评分比较差异有统计学意义(P<0.05);分组与时间之间无交互作用(P>0.05)。结论:舒芬太尼和吗啡应用于先天性心脏病小儿术后镇痛患儿生命体征平稳,术后疼痛轻,镇静效果好,且大剂量舒芬太尼镇痛效果更佳。
Objective： To study the effect of.sufentanil and morphine for postoperative analgesia in children with congenital heart disease, and to evaluate its safety and effectiveness. Methods： One hundred and twenty cases of children of ventricular septal defect repair of congenital heart disease in our hospital from January 1,2011 to December 31, 2012 were selected and randomly divided into small doses sufentanil group （group A）, large doses sufentanil group （group B ）, morphine group （group C ）, 40 cases in each group. Three groups of children＇ s vital signs, pain score, sedation scores and other indicators were analyzed and compared. Results： There was no statistical significance of three groups with HR, MAP and SpO2（ P〉0.05 ） , SpO2 and HR, MAP, SpO2 in different time point had no statistical significance （ P〉0. 05 ）, and there was no significant interaction between group and time （P〉0. 05 ）. Differences of three groups of FLACC scores were statistically significant （P〈O. 05）, in which the group B〈 group A 〈 group C, differences of FLACC scores in different points were statistically significant （P〈0. 05）, and there was no significant interaction between group and time （ P〉 0.05 ）. Difference of three groups of Ramsay score had no statistical significance （ P〉O. 05 ） , there was no difference between group A and group B （P〉O. 05 ）, group A and group C （P〉0. 05 ）, group B and group C （P〉O. 05 ）. Differences of Ramsay scores in the different time points were statistically significant （P〈0. 05）, there was no different interaction between group and time （P〉0. 05）. Conclusion： Sufentanil and morphine used in children with congenital heart disease for postoperative analgesia, children＇ s vital signs are stable, postooerative pain are light, sedative effect are good. and the high dose of sufentanil has better analgesic effect.
出处
《儿科药学杂志》
CAS
2015年第6期14-17,共4页
Journal of Pediatric Pharmacy
关键词
舒芬太尼
吗啡
儿童
先天性心脏病
Sufentanil
Morphine
Children
Congenital heart disease
