摘要
目的:研究雷公藤多苷片联合低分子肝素治疗小儿紫癜性肾炎的临床疗效及免疫调节机制。方法:选取我院儿科收治的70例患儿,随机分为对照组34例和研究组36例。对照组给予常规处理措施联合雷公藤多苷片口服治疗,研究组在对照组基础上给予静脉输注低分子肝素钙治疗,比较两组患儿临床疗效及治疗前、治疗12周后免疫指标变化情况。结果:研究组、对照组治疗总有效率为88.9%及67.6%,两组比较差异有统计学意义(χ2=4.69,P<0.05)。研究组治疗12周后IL-6、IL-18、TNF-α水平分别为(19.3±2.6)pg/m L、(37.9±7.6)pg/m L、(2.5±0.9)pg/m L,均较对照组明显下降(P<0.05);IL-10水平为(76.3±22.7)pg/m L,较对照组明显升高(P<0.05)。结论:雷公藤多苷片联合低分子肝素钙治疗小儿紫癜性肾炎临床效果较满意,可有效改善其免疫炎症指标,具有较高的临床推广价值。
Objective: To research clinical efficacy and immune regulation mechanisms of tripterygium glycosides tablet combined with low molecular weight heparin calcium in the treatment of children with purpura nephritis. Methods: A total of 70 cases of children with purpura nephritis was selected in this study and randomized divided into control group and observation group. Thirty-four cases of children in the control group,received conventional treatment measures combined with oral tripterygium glycosides tablet therapy,36 children in observation group received conventional treatment measures combined with oral tripterygium glycosides tablet and infusion low molecular weight heparin calcium therapy. Compared clinical efficacy and immune inflammatory markers of two groups before and after treatment in 12 weeks. Results: The total effective rate of the observation group and the control group were 88. 9%,67. 6%,there were significantly different between two groups( P<0. 05). The levels of IL-6,IL-18,TNF-( after treatment in 12 weeks of the observation group were( 19. 3±2. 6) pg / m L,( 37. 9±7. 6) pg / m L,( 2. 5±0. 9) pg / m L,the levels compared with the control group had decreased significantly. IL-10 levels after treatment was( 76. 3 ± 22. 7) pg / m L,it was significantly improved compared with the control group,there were statistically significant( P < 0. 05). Conclusion: The clinical results of tripterygium glycosides tablet combined with low molecular weight heparin calcium therapy is satisfactory,which can effectively improve the immune and inflammatory indicators,it has a high clinical value.
出处
《儿科药学杂志》
CAS
2015年第6期32-35,共4页
Journal of Pediatric Pharmacy
关键词
小儿
紫癜性肾炎
免疫抑制
抗凝
Children
Purpura nephritis
Immunosuppression
Anticoagulant
