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几种常用崩解剂的理化性能和应用效果 被引量:12

Properties and Application of Commonly Used Disintegrants
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摘要 目的考察市面常用崩解剂的理化性能和应用效果。方法采用显微镜观察崩解剂的微观形态,采用马尔文激光粒度仪测定粒径及分布;以吸水膨胀为评价指标,研究其吸水性、流动性和可压性;以磷酸氢钙为模型药物,研究崩解剂种类和用量对崩解时间的影响。结果低取代羟丙基纤维素为长纤维状粉末,粒径范围广,相对而言流动性较差,可压性较好,具有较大的表面积,使片剂易于成型,加大片剂崩解后的分散度;羧甲基淀粉钠为类椭球状粉末,粒径分布较均匀,吸水性和流动性很好,能够显著加快片剂的崩解。结论在选择崩解剂时,不仅要考虑崩解剂的种类,还要选择崩解剂的型号、用量、来源。 Objective To evaluate the properties and application of commonly used disintegrants in markets. Methods Microscope was used to observe the microstructure of disintegrants. Melvin Laser Granulometer was used to measure the particle size and distribution. Water swelling was used as index to study the hydroscopicity,flowability and compactability. Calcium hydrogen phosphate was used as model drug to evaluate the effects of kinds and amounts of disintegrants on disintegrating time. Results Low-substituted hydroxypropyl cellulose was long ifbrous powder, with less lfowability and better compactability. Carboxymethyl starch sodium was elliptic spherical powder, with uniform particle size distribution, good liquidity and water imbibition. Conclusions Not only Kinds and types of disintegrants, but also dosage and source should be taking into consideration when choosing disintegrants.
出处 《中国医药指南》 2015年第16期20-22,共3页 Guide of China Medicine
关键词 崩解剂 微观形态 膨胀性 粉体学性质 崩解性能 Disintegrants Micromorphology Expansibility Powder property Disintegration characteristic
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