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微循环功能障碍与糖尿病研究进展 被引量:14

Microcirculation dysfunction and diabetes mellitus
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摘要 微循环功能障碍参与了糖尿病及其并发症的发病机制,其机制包括胰岛微循环功能异常影响胰岛β细胞的生理功能、微血管自律运动功能受损导致外周肌肉组织胰岛素抵抗、靶器官微循环功能障碍引起的靶细胞进行性损伤等。 Microcirculation dysfunction is involved in the onset of diabetes and its complications. The pathophysiological mechanisms behind the relationship between microcirculation and diabetes are multifactorial. Islet microcirculation dysfunction affects function of islet β cells. Impairment of microvascular vasomotion might be associated with insulin resistance. Microcirculation dysfunction of target organs mediates diabetic complications.
机构地区 中国医学科学院
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2015年第5期471-473,共3页 Chinese Journal of Endocrinology and Metabolism
关键词 糖尿病 微循环 发病机制 Diabetes mellitus Microcirculation Pathogenesis
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  • 1Sims DE.Diversity within pericytes[J].Clin Exp Pharmacol Phys-iol,2000,27(10):842-846.
  • 2Ehler E,Karlhuber G,Bauer HC,et al.Heterogeneity of smoothmuscle-associated proteins in mammalian brain microvasculature[J].Cell Tissue Res,1995,279(2):393-403.
  • 3Bandopadhyay R,Orte C,Lawrenson JG,et al.Contractile proteinsin pericytes at the blood-brain and blood-retinal barriers[J].JNeurocytol,2001,30(1):35-44.
  • 4Hughes S,Gardiner T,Hu P,et al.Altered pericyte-endothelial re-lations in the rat retina during aging:implications for vessel stabili-ty[J].Neurobiol Aging,2006,27(12):1838-1847.
  • 5Donoghue L,Tyburski JG,Steffes CP,et al.Vascular endothelialgrowth factor modulates contractile response in microvascular lungpericytes[J].Am J Surg,2006,191(3):349-352.
  • 6Markhotina N,Liu GJ,Martin DK.Contractility of retinal pericytesgrown on silicone elastomer substrates is through a protein kinaseA-mediated intracellular pathway in response to vasoactive peptides[J].IET Nanobiotechnol,2007,1(3):44-51.
  • 7Kawamura H,Sugiyama T,Wu DM,et al.ATP:a vasoactive signalin the pericyte-containing microvasculature of the rat retina[J].JPhysiol,2003,551(Pt 3):787-799.
  • 8Foo SS,Turner CJ,Adams S,et al.Ephrin-B2 controls cell motilityand adhesion during blood-vessel-wall assembly[J].Cell,2006,124(1):161-173.
  • 9Edelman DA,Jiang Y,Tyburski J,et al.Pericytes and their role inmicrovasculature homeostasis[J].J Surg Res,2006,135(2):305-311.
  • 10Kerkar S,Speyer C,Tyburski J,et al.Reactive oxygen metabolitesinduce a biphasic contractile response in microvascular lung peri-cytes[J].J Trauma,2001,51(3):440-445.

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