摘要
背景:毛囊干细胞来源于皮肤、毛发,数量极其可观,取材后无严重的并发症和免疫原性,可供自体移植,是最容易获取的干细胞来源之一。目的:综述毛囊干细胞促进皮肤伤口修复的作用因素,以期为该领域研究提供有效的实验依据。方法:应用计算机以"毛囊干细胞、皮肤修复、再生医学、组织工程"或"hair follicle stem cell,skin repairing,regenerative medicine,tissue engineering"为检索词检索CNKI和PubM ed数据库1999年1月至2014年12月发表的关于毛囊干细胞促进皮肤伤口修复的文章,最终选择45篇文章进行综述。结果与结论:毛囊干细胞作为一种容易获得、数量可观、使用较为安全以及具有分化潜能的成体干细胞,可以通过皮肤早期血管化、表皮及附属器官的再生、信号通路作用及转录因子调节等方面的影响,促进皮肤伤口的修复,能为再生医学及组织工程研究提供良好的种子细胞。
BACKGROUND：Hair fol icle stem cel s derived from skin and hair have the most readily available sources, and cannot lead to serious complications and immunogenicity after col ection, which can be used for autologous transplantation. OBJECTIVE：To provide effective experiment basis for hair fol icle stem cel s in the repair of skin wound through reviewing the role of hair fol icle stem cel s in promote the repair of skin wound. METHODS：Articles related to hair fol icle stem cel s for the repair of skin wound were retrieved in CNKI and PubMed databases （1999-01/2014-12）. The key words were“hair fol icle stem cel , skin repairing, regenerative medicine, tissue engineering”in Chinese and English, respectively. A total of 45 articles based on inclusion criteria and exclusion criteria were obtained for the review. RESULTS AND CONCLUSION：Hair fol icle stem cel s belong to adult stem cel s, which are easy to access, have a significant number, and possess differentiation potential and safety. Hair fol icle stem cel s can promote the repair of skin wound and provides good seed cel s for regenerative medicine and tissue engineering research through early vascularization of the skin, epidermal and appendage regeneration, signaling pathways, and transcription factors.
出处
《中国组织工程研究》
CAS
北大核心
2015年第14期2278-2282,共5页
Chinese Journal of Tissue Engineering Research
基金
浙江省科技厅公益技术应用研究社会发展项目(2010C330133)
杭州市萧山区社会发展重大科技攻关项目(2014205)~~
