摘要
咔咯及其金属配合物与DNA相互作用和它们的抗肿瘤活性研究已成为咔咯大环化学前沿课题之一。本文综述了咔咯及其金属配合物与DNA相互作用和关于这类化合物在抗肿瘤方面的研究进展,系统介绍了咔咯及其金属配合物与DNA结合模式、在氧化剂存在或光照条件下的核酸酶活性、与G-四链体DNA相互作用以及这类化合物抗肿瘤活性。
Study on the interaction of corrole and its metal complex with DNA and their anti-tumor activity has become one of the hot topics of corrole chemistry. This review covers the progress on the study of the interaction of corrole and its metal complex with DNA and their anti-tumor activity. The binding mode of corrole or its metal complex with DNA, chemical nuclease activity of corrole and its metal complex in the presence of oxidants or under irradiation, the interaction of corrole and its metal complex with G-quadruplex DNA and their anti-tumor activity are introduced systematically.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2015年第6期755-762,共8页
Progress in Chemistry
基金
国家自然科学基金项目(No.21171057
21371059)
广东省自然科学基金(No.S2012040006270)资助~~
