摘要
目的:评价氟哌啶醇联合氯硝西泮治疗食管癌术后精神障碍的有效性。方法:选择34例发生术后精神障碍的食管癌患者临床资料进行回顾性研究,分析性别、年龄、饮酒、吸烟、病理分期等因素与术后精神障碍发生的关系,以及氟哌啶醇联合氯硝西泮在治疗食管癌术后精神障碍中的疗效。结果:34例发生术后精神障碍的患者占同期所有食管癌手术患者的5.5%(34/618);男性患者术后精神障碍总体发生率高于女性,但非饮酒的男性患者与女性患者术后精神障碍发生率的差异无统计学意义(P>0.05);高龄(≥65岁)患者术后精神障碍发生率高于低龄(<65岁)患者,差异具有统计学意义(P<0.05);术前饮酒者的术后精神障碍发生率高于非饮酒者,差异具有统计学意义(P<0.05);是否吸烟和病理分期对术后精神障碍的发生差异无统计学意义(P>0.05)。所有术后精神障碍的患者经单用氟哌啶醇或联合氯硝西泮治疗,精神状态均完全恢复正常。结论:高龄、饮酒是食管癌术后精神障碍发生的危险因素,单用氟哌啶醇或联合氯硝西泮是食管癌术后急性精神障碍安全、有效的药物治疗方案。
OBJECTIVE： To evaluate the efficacy and safety of haloperidol combined with clonazepam in the treatment of post-operative delirium in esophageal cancer. METHODS： The clinical information of 34 patients with post-operative delirium in esophageal cancer were retrospective analyzed to analyze the relationships between personal characteristics （including gender, age, alcohol use, smoking, pathological stages） and the incidence of post-operative delirium and the efficacy of haloperidol combined with clonazepam in the treatment of post-operative delirium. RESULTS： The incidence rates of post-operative delirium of 34 pa- tients were 5.5% （34/618）; the total incidence rate of post-operative delirium in male patients was significantly higher than that fe- male patients and there was no significant difference between the incidence of non-alcohol user male patients and female patients （P〉0-05） ; the incidence of post-operative delirium in elder patients （ 〉65 age） was higher than younger patients （ 〈65 age）, with significant difference （P〈0-05） ; the incidence of alcohol user was higher than non-alcohol user, with significant difference （P〈0-05） ; there was no significant difference between the smoking and pathological stages and the incidence of post-operative delirium （P〉0-05） ; the mental status of all patients with post-operative delirium was recovered completely after the treatment of only haloperidol or combined with clonazepam. CONCLUSIONS： Elder age and alcohol use are risk factors of post-operative delirium in esophageal cancer. Only haloperidol or combined with clonazepam is the safe and effective regimen of acute post-operative delirium in esophageal cancer.
出处
《中国药房》
CAS
北大核心
2015年第17期2381-2383,共3页
China Pharmacy
关键词
食管癌
术后精神障碍
危险因素
氟哌啶醇
氯硝西泮
Esophageal cancer
Post-operative delirium
Risk factors
Haloperidol
Clonazepam
