摘要
目的：探讨白芍总苷对银屑病IL－8、TNF－α的影响，同时评价白芍总苷治疗银屑病的临床疗效。方法选取2013年1月至2014年8月我院皮肤科诊断的中、重度寻常型斑块状银屑病患者48例，随机分为A、B、C三组。 A组：每周1次口服甲氨喋呤7.5 mg；B组：口服白芍总苷（0.4-0.6） g/d；C组：口服白芍总苷（0.4-0.6） g/d，同时每周1次口服甲氨喋呤7.5 mg。ELISA法检测48例银屑病患者治疗前后TNF－α和IL－8水平，同时检测15名健康志愿者作为正常对照组。比较三组临床治疗效果。结果 A组的治疗有效率为50.0％，B组及C组分别为81.3％、87.5％，B组与C组相比有效率差异无统计学意义（ P〉0.05）；而B、C组分别与A组比较，有效率差异均有统计学意义（ P〈0.05）。银屑病患者治疗前血中TNF－α、IL－8含量明显高于治疗后及正常对照组，治疗前后比较差异有显著性（ P〈0.01）。银屑病患者治疗后血清TNF－α、IL－8含量与正常人对照差异无显著性（ P〉0.05），但治疗后血清TNF－α、IL－8仍高于正常人。结论 TNF－α、IL－8可能与银屑病的活动性有关，参与了银屑病的病理生理过程，在发病过程中起重要的作用。白芍总苷治疗银屑病效果显著，结合甲氨蝶呤治疗效果更明显，可能通过降低TNF－α、IL－8而发挥作用。
objective To investigate the effect of total glucosides of paeony on the serum level of IL-8 and TNF-αin the patients with psoriasis,and evaluate the clinical curative effect. Methods 48 patients with moderate and se-vere plaque psoriasis from January to August 2013 in our department were randomly divided into A, B, C three groups.The patients were treated with oral methotrexate of 7.5 mg once a week in group A. The patients in group B were treated daily with oral total glucosides of paeony of 0.4-0.6 g and the paitient in group C were treated daily with oral oral total glucosides of paeony of 0.4-0.6 g,combine with oral methotrexate 7.5 mg once a week. The serum level of TNF-αand IL-8 of 15 healthy volunteers and 48 patients with psoriasis before and after treatment was detected by ELISA method. The clinical therapeutic effect was compared in three groups. Results The effective rate was 50.0%,81.3% and 87.5% in group A,B and C separately. There was no significant difference between group B and group C （ P〉0.05） . Compared with that of group A,the effective rate of B and C group had statistical significance （ P〈0.05） . The serum concentration of TNF-α and IL-8 was higher in untreated patients with psoriasis, than that of treated patient with psoriasis and normal controls, and there was significant difference between treaed and untreated patients （ P〈0.01） . Compared with normal control,the serum concentration of TNF-α and IL-8 was stiil higher in treated patients with psoriasis,but there was no significant difference （ P〉0.05） . Conclusion TNF-αand IL-8 may be invoved in the pathogenesis of psoriasis,and play an important role in the development of disease. The effect of total glucosides of paeony on the treatment of psoriasis was remarkable,especially combined with methotrexate.
出处
《皮肤病与性病》
2015年第3期133-135,共3页
Dermatology and Venereology
基金
梅州市科技计划项目项目编号:2013B43
