摘要
目的:观察茵陈蒿冲剂联合血红素加氧酶抑制剂治疗新生儿黄疸的临床疗效。方法:选取2012年11月—2014年5月在本院接受治疗的新生儿病理性黄疸患者120例,随机分为对照组和试验组各60例,对照组采用茵陈蒿冲剂治疗,试验组采用血红素加氧酶抑制剂联合茵陈蒿冲剂治疗,比较临床疗效及血清总胆红素、直接胆红素、间接胆红素的变化情况。结果:治疗后两组总胆红素、间接胆红素、直接胆红素显著下降,组间比较有显著差异(P<0.05);试验组有效率高于对照组(P<0.05),差异具有统计学意义;试验组的黄疸持续时间明显短于对照组,每天排便次数明显多于对照组(P<0.01),差异具有统计学意义;试验组住院时间明显短于对照组,住院费用明显高于对照组(P<0.01),具有统计学意义。结论:茵陈蒿冲剂联合血红素加氧酶抑制剂治疗新生儿黄疸安全、经济、有效,能够明显改善患者的血胆红素水平和黄疸持续时间,从而预防高胆血红症,疗效显著。
Objective： To observe the clinical efficacy of Yinchenhao Granules combined with heme oxygenase（ HO） inhibitors in the treatment of neonatal jaundice. Methods： A total of 120 infants with neonatal jaundice admitted in our hospital from November,2012 to May,2014 were selected and randomly divided into control group and experimental group,60 cases for each group.Control group was treated with Yinchenhao Granules,on which basis experimental group was added with HO inhibitors. The clinical efficacy,total serum bilirubin and direct and indirect bilirubin between two groups were compared. Results： After treatment,total serum bilirubin and direct and indirect bilirubin decreased evidently in both groups than treatment before,and there were also significant differences between two groups（ P〈0. 05）. The clinical efficacy was markedly higher in experimental group than in control group（ P〈0. 05）. Experimental group was apparently shorter in duration of jaundice but higher in the daily defecation times than control group（ P〈0. 01）. In addition,experimental group was significantly shorter in hospital stays but obviously higher in hospitalization costs than control group（ P〈0. 01）. Conclusio： Yinchenhao Granules combined with HO inhibitors are safe,economic and effective in treating infants with neonatal jaundice because they can significantly improve the serum bilirubin level and duration of jaundice so as to prevent hyperbilirubinemia,with favorabl efficacy obtained.
出处
《河南中医》
2015年第5期1159-1161,共3页
Henan Traditional Chinese Medicine
